IL-6 Signaling Overview Interleukin-6 (IL-6) is an endogenous chemical with multiple forms and functions. It acts as both a pro and an anti-inflammatory cytokine (1). In the early phase of infectious inflammation, IL-6 is produced by monocytes and macrophages immediately after the stimulation...
Interleukin-6 (IL-6) plays a critical role in the pathogenesis of various chronic inflammatory diseases, tracked across numerous fields of research. Despite this, a crucial aspect often overlooked in studies is the differentiation between IL-6 classic-signaling and trans-signaling, leading to ...
The pathway also mediates signaling by interferons, which are used as antiviral and antiproliferative agents. Researchers have found that dysregulated cytokine signaling contributes to cancer. Aberrant IL-6 signaling contributes to the pathogenesis of autoimmune diseases, inflammation, and cancers such as ...
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Explore the IL-6 signaling pathway and find antibodies to detect some of its target proteins, including IL-6, IL-6RAlpha, GP130, and AKT.
[2] Jones, Simon A., Jürgen Scheller, and Stefan Rose-John. "Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling." The Journal of clinical investigation 121.9 (2011): 3375-3383.[3] Du, Qingqing, Yan Qian, and Weiwei Xue. "Molecular simulation of oncostatin M and ...
本期胸小星将为大家带来二甲双胍通过抑制IL-6信号通路下调食管鳞癌中PD-L1 的表达;整合肿瘤异质性预测食管鳞癌患者的复发,一起来看看吧! 2017·EATTS 01 Metformin Downregulates PD-L1 Expression in Esophageal Squamous Cell Catrci...
H. Leonhardt, C.F. Calkhoven, E. Noessner, T. Brocker, J. Huehn, A. B. Krug, M. Zavolan, D. Baumjohann, V. Heissmeyer, Roquin suppresses the PI3K-mTOR signaling pathway to inhibit T helper cell differentiation and conversion of treg to Tfr cells, Immunity 47 (6) (2017) 1067–...
2022年5月,哈尔滨医科大学附属二院吴健教授团队在Cellular and Molecular Life Sciences杂志上发表了题为“Mettl14 mediates the inflammatory response of macrophages in atherosclerosis through the NF-κB/IL-6 signaling pathway”的文章。...
近日,来自中国电子科技大学的研究者们在J Exp Clin Cancer Res 杂志上发表了题为“Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2/STAT3/Sox4/NLRP3 signaling pathway”的文章,该研究通过激活JAK2/STAT3/Sox4/NLRP3通路证实了IL-6在口腔鳞癌进展中的致癌作...