The present work establishes a role of IL-6/ERK signaling in promoting M2-like macrophage polarization, and suggests this axis as a potential therapeutic target for combination with IFN-I-based cancer treatments.doi:10.1038/s41598-022-23721-9Limin Yang...
Contents lists available at ScienceDirectCancer Lettersjournal homepage: www.elsevier.com/locate/canletOriginal ArticlesIL-6 induced M1 type macrophage polarization increases radiosensitivity inHPV positive head and neck cancerXiaohang Chen a,b , Enhui Fu a , Huihuang Lou a , Xionghui Mao c , Bing...
The survival rate was improved by the treatment of IL-6-deficient mice with a NO production-specific inhibitor. Our data revealed that IL-6 regulates the excessive release of NO through IL-1β inhibition and determines the establishment of an M2 macrophage profile within infected heart tissue. ...
of M2 macrophage infiltration in cancer tissues. In order to explore whether IL-6 have an 第三军医大学硕士学位论文 4 effect on M2 macrophages polarization, we established macrophage differentiation model in vitro. Through detecting the phenotype of the IL-6 induced macrophage, we found that...
Conclusion: Intermittent hypoxia acts as a potent proinflammatory stimulus, resulting in IL-6 induction and M1 macrophage polarization. Increased IL-6 expression may be due to both induction of antioxidant response element and nuclear factor kappa B as well as inhibition of miR-365 expression. ...
S2M–O). Thus, IL-21 signaling is not required to prevent the development of Th2 cell responses to HDM, while IL-6 signaling is. Fig. 2 IL-6 signaling in allergen-specific T cells suppresses Th2 cell polarization. (A-G) Lckcre-Il6rfl/fl and control mice were i.n. sensitized with...
2. Murray, P.J., Allen, J.E., Biswas, S.K., Fisher, E.A., Gilroy, D.W., Goerdt, S., Gordon, S., Hamilton, J.A., Ivashkiv, L.B., Lawrence, T., et al. (2014). Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41, 14–20. https:...
随后,应用细胞因子抗体芯片技术检测PKCβⅡ高表达后细胞因子分泌的变化,结果表明,IL-6升高最显著,普遍上调的促炎因子还包括IL-8、粒细胞-巨噬细胞集落刺激因子(granulocyte-macrophage colony-stimulating factor, GM-CSF)、粒细胞集...
题目:Interleukin 37 Suppresses M1 Macrophage Polarization Through Inhibition of the Notch1 and Nuclear Factor Kappa B Pathways 影响因子:6.68 分区:Q2 ;中科院2区 01 摘要 巨噬细胞介导的慢性炎症在心血管疾病中起着重要作用,包括加速钙化性主动脉瓣...
In conclusion, IL-6 cooperated with M-CSF could induce CD14+monocytes differentiate to M2-like(IL-10 high TGF-β high IL-12 low ) macrophages by activating STAT3 signal pathway.[Key words] IL-6; STAT3; Macrophage; M2 polarization巨噬细胞是免疫系统的主要组成部分,其发挥重要的防御功能。对巨...