Once the polarization of macrophages is imbalanced, the resulting immune dysregulation will cause inflammatory stimulation, and release a large amount of inflammatory factors affecting bone metabolism, leading to pathological conditions such as osteoporosis (OP), rheumatoid arthritis (RA), and steroid-...
MACROPHAGESIMMUNE systemMacrophages are critical components of the immune system and play vital roles in pathogen defense, immune regulation, and tissue repair. These cells exhibit different polarization states depending on environmental signals, and the M1/M2 paradigm is a usef...
Finally, we assessed transcriptional changes in key immune pathways throughout tumor progression along the trajectory. It has been widely appreciated during recent years that cancer growth is supported by changes in the tumor microenvironment, such as the polarization of macrophages from an M1— towards...
At day 14, M2 macrophages gradually became the dominant cell population, which suppressed inflammation and promoted revascularization and fat regeneration. In addition, transcriptome sequencing showed that the differentially expressed genes in the Rosiglitazone group were associated with the pathways of ...
165Takano et al. showed that CRC-derived exosomes delivered miR-203 into monocytes and that miR-203 could induce the polarization of macrophages to M2-tumor-associated macrophages (TAMs), which exert prometastatic functions.166They also observed the tendency of miR-203-transfected CRC CTCs to ...
Consequently, we hypothesized that geniposide might regulate the polarization of macrophages through certain signaling pathways, further alleviating AS. Therefore, the current work aimed to provide insights into geniposide’s effects on plaque stability in New Zealand rabbits with high-fat diet induced AS...
Cellular metabolism and macrophage functional polarization. Macrophages are a functionally heterogeneous cell population that is mainly shaped by a variety of microenvironmental stimuli. Interferon γ (IFN-γ), inte... Linnan,Zhu,Qingjie,... - 《International Reviews of Immunology》 被引量: 79发表:...
macrophages are essential for the onset and development of periodontitis.They can release a large number of inflammatory factors to damage periodontal tissues and produce some bactericidal substances to inhibit and kill pathogenic microbes.This review presents the role of macrophage polarization in the ...
On the other side macrophages must avoid too much iron, as this would favor growth and maturation of intracellular pathogens, which no longer can be killed (Alford et al., 1991, Paradkar et al., 2008). Thus, the processes of macrophage polarization and their role in immunity are closely ...
Classical M1 and alternative M2 activation of macrophages, mirroring the Th1-Th2 polarization of T cells, represent two extremes of a dynamic changing state of macrophage activation. M1-type macrophages release cytokines that inhibit the proliferation of surrounding cells and damage contiguous tissue, ...