PolarizationImmunotherapyProliferationMacrophages are a key component of the osteosarcoma immune microenvironment.Understanding macrophage origins, proliferation capacity and high plasticity is crucial for further research.Macrophages promote the formation of the pre-metastatic niche.Macrophages have potential anti-...
内容提示: 细胞生物学杂志Chi neseJ ournal of Cel lBi ol ogy2007,29:27—30http://w w w .cj cb.org巨噬细胞的极化及其意义张凤熊思东·(复旦大学免疫生物学研究所,免疫学系,上海200032)摘要表型可变性和功能多样性是单个核吞噬细胞的重要特征。近年来巨噬细胞的极化受到关注。一般认为极化巨噬细胞是单核...
At the early stage of tumor progression, macrophages are primarily polarized to the M1 type, while as the tumor progresses, they gradually evolved into M2-like TAMs [16]. The polarization of macrophages is regulated by various factors, including extracellular cytokines, proteases, exosomes in the ...
POLARIZATION OF MACROPHAGES TO A HEALING PHENOTYPE BY CARDIOSPHERE-DERIVED CELLS AND BY THE EXOSOMES SECRETED BY SUCH CELLSDescribed herein are compositions and techniques related to generation and therapeutic application of stem cell-derived exosomes. The Inventors have discovered cardiosphere-derived cells...
the polarization of macrophages becomes dysregulated, hindering the transition from the inflammatory to proliferative phase and consequently delaying the wound healing process. Consequently, regulating macrophage polarization is often regarded as a potential target for the treatment of diabetic wounds. The rol...
Aims. To investigate the effect of GLP-1/GLP-1R on the polarization of macrophages in the occurrence and development of atherosclerosis. Methods. Totally, 49 patients with coronary heart disease (CHD) and 52 cases of health control (HC) were recruited, all subjects accept coronary angiography go...
Finally, we assessed transcriptional changes in key immune pathways throughout tumor progression along the trajectory. It has been widely appreciated during recent years that cancer growth is supported by changes in the tumor microenvironment, such as the polarization of macrophages from an M1— towards...
Resveratrol also led to the polarization of macrophages to the M2 direction, as well as decreasing the expression of a number of M1 pro-inflammatory cytokines [tumor necrosis factor α (TNF-α), interleukin 1 β (IL-1β) and interleukin 6 (IL-6)]. In addition, increased infiltration of ...
The neural and endocrine systems also participate in the polarization of macrophages. The α7nAChR is an acetylcholine (ACh) receptor expressed on tissue macrophages. Activation of the receptor can inhibit the polarization of M1 induced by LPS and promote the polarization of M2 [79]. Glucocorticoid...
As already stated above, TAMs are a heterogeneous population, based not only upon their origin and localization within the tumor, but also on their functions. Initially, upon activation, TAMs were classified into two different phenotypes: (1) a pro-inflammatory M1 phenotype/polarization, characterize...