研究小组认为IL-21 对 Tfh 细胞分化的贡献取决于伴随B细胞反应，因为前人的研究证明生发中心的B细胞 和 Tfh 细胞状态关系密切【3】，Isaak Quast教授的研究结果证明当IL-21信号仅作用于T细胞时，B细胞增殖及浆细胞分化作用最明显。相比与B细胞IL-21R信号通路，增加Tfh细胞数量可以更好的促进B细胞的分化。IL-21通过...
B cellsCELL populationsCYTOKINESAUTOIMMUNE diseasesCELLULAR immunityThe article discusses the study which reveals that interleukin-21 (IL-21) promotes an expanded B10 cell population. The researchers have cultured B cells with ...
Danijela, et al. IL-21: An Executor of B Cell Fate. The Journal of Immunology.Davide, et al...
作者首先利用IL-21-KO 和IL-21R-KO 小鼠和OT-II-OVA系统以及过继回输,证明了IL-21可以直接作用于T细胞促进Tfh细胞扩增,而不通过B细胞介导。作者又对IL21-KO作用的OT-II T细胞和对照组进行了转录组分析,分析发现共391个差异基因,其中256个基因表达上升,135个基...
它可以通过由IL-21R和普通γ链/IL-2Rγ组成的受体复合体激活下游信号通路。IL-21由活化的CD4+ T细胞、NKT细胞或滤泡辅助性T细胞分泌,对淋巴细胞和骨髓细胞具有多种生物学效应,如其与受体结合后能够调节B细胞增殖,分化成浆细胞来启动免疫应答。IL-21还能促进CD8+ T细胞和NK细胞的增殖、分化,提高NK细胞的杀伤活性...
它可以通过由IL-21R和普通γ链/IL-2Rγ组成的受体复合体激活下游信号通路。IL-21由活化的CD4+ T细胞、NKT细胞或滤泡辅助性T细胞分泌,对淋巴细胞和骨髓细胞具有多种生物学效应,如其与受体结合后能够调节B细胞增殖,分化成浆细胞来启动免疫应答。IL-21还能促进CD8+ T细胞和NK细胞的增殖、分化,提高NK细胞的杀伤活性...
G, Li ZJ et al,PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21.JCI Insight. 2019 Oct 17;4(20):e130062. Xueyang Zou et al,The role of follicular T helper cells in the onset and treatment of type ...
Danijela, et al. IL-21: An Executor of B Cell Fate. The Journal of Immunology. Davide, et al. IL-21 as a therapeutic target in inflammatory disorders. Expert Opin. Ther. Targets. LI-NA WANG. et al. Interleukin 21 and Its Receptor Play a Role in Proliferation, Migration and Invasion ...
4. Danijela, et al. IL-21: An Executor of B Cell Fate. The Journal of Immunology. 5. Davide, et al. IL-21 as a therapeutic target in inflammatory disorders. Expert Opin. Ther. Targets. 6. LI-NA WANG. et al. Interleukin 21 and Its Receptor Play a Role in Proliferation, Migration...
它可以通过由IL-21R和普通γ链/IL-2Rγ组成的受体复合体激活下游信号通路。IL-21由活化的CD4+ T细胞、NKT细胞或滤泡辅助性T细胞分泌,对淋巴细胞和骨髓细胞具有多种生物学效应,如其与受体结合后能够调节B细胞增殖,分化成浆细胞来启动免疫应答。IL-21还能促进CD8+ T细胞和NK细胞的增殖、分化,提高NK细胞的杀伤活性...