While the helper CD4 T cells did not require Bcl6, the same was not true for the Tbet+ B cells, as Tbet+ memory B cells were not generated in the absence of B cell-intrinsic Bcl6. These data suggest that T-bet B cells require a novel transcriptional program whereby Tbet and Bcl6...
在T细胞中,IL-21可以作为促有丝分裂的辅助因子,与IL-7和UK-15协同作用,促进CD8+T细胞扩增,促进Th17细胞分化,并诱导BCL6的表达,促进滤泡辅助T细胞扩增。在B细胞中,IL-21能够促进浆细胞分化,与IL-4共同作用调节IgG1和IgG3转换。另外,IL-21还能够增强NK细胞和NKT细胞的细胞毒活性,诱导树突状细胞凋亡。
在T细胞中,IL-21可以作为促有丝分裂的辅助因子,与IL-7和UK-15协同作用,促进CD8+T细胞扩增,促进Th17细胞分化,并诱导BCL6的表达,促进滤泡辅助T细胞扩增。在B细胞中,IL-21能够促进浆细胞分化,与IL-4共同作用调节IgG1和IgG3转换。另外,IL-21还能够增强NK细胞和NKT细胞的细胞毒活性,诱导树突状细胞凋亡。
(URSA)患者绒毛中滤泡辅助性 T(follicular helper T,Tfh)细胞相关因子白介素-21(interleukin-21,IL-21)、趋化因子受体-5(CXC chemokine receptor-5,CXCR5)、B 细胞淋巴瘤分子6(B cell lymphoma 6,Bcl-6)和 B 淋巴细胞诱导成熟蛋白1(B lymphocyte-induced maturation protein 1,Blimp-1)的表达...
本研究目前发现外周血的检测因子与视网膜 蓝光损伤具有相关性 ,但其中的作用信号通路需 进一步的研究.有研究 表[21] 明 ICOS 信号对于激 活 Tfh 谱系转录因子 Bcl6 的早期诱导至关重要, Bcl6 随后上调 CXCR5 的表达,同时在 Tfh 细胞上 表达 ICOS 有助于维持 Tfh 分化 .[20] 因此,为进一 步探讨 Tfh ...
In mouse models, IL-21 regulates the GC response by maintaining expressions of transcription factors B cell lymphoma-6 (BCL-6) and AP-4 in GC B cells, which are critical for GC persistence, function, and output (25–28). As a potent inducer of B cell proliferation (29, 30), IL-21...
The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma. Oncogene. 2002;21:368–76. Article CAS Google Scholar Wang T, Cunningham A, Houston K, Sharma AM, Chen L, Dokun AO, et al. ...
In contrast to T-bet+T cells, T-bet+B cells did not develop in the absence of B cell-intrinsic Bcl-6 but were generated in the absence of T-bet. T-bet-deficient memory B cells were largely indistinguishable from their wild-type counterparts, although they no longer underwent switching ...
Abstract Interleukin (IL)-21 is a new member of the type I cytokine superfamily. Although it is most homologous to IL-15, it has a unique receptor chain, IL-21R, that pairs with the γ-common cytokine receptor chain. The first experiments examining the biology of the IL-21 pathway revea...
IRF4 then down-regulates Bcl6, a repressor of STAT3, IRF4 and Blimp1 which are important factors for PC development (Ding et al., 2013). However, as part of this interaction, certain soluble cytokines produced by Tfh cells such as interleukin 2 (IL-2), IL-4, IL-10, IL-13 or IL...