内容提示: IL-2R b bIL-2R g gIL-2R a aPc-JunPPSTAT5NF- k k BPPc-Mycc-Fosc-JunElk1PJAK1I k k BDegradationAkt/PKBPathwaySHCGTPGeneExpressionCytokineProductionPIP2PTENLckDAGPLC- g gSTAT5NFATc-FosElk1MEKsIKKsRaf1Ca 2 +SOSGRB2ERKsPIP3CalcineurinJNKPI3KIL-2IL-2 PathwaySTAT5STAT5Pc-...
产品名称: HS IL-2 PATHWAY, FAST .0 订购此产品 供应商: Invitrogen 规格: EACH 目录价: 3283 库存状态: 三周到货 CAS编号: 应用范围: 生化试验 种属来源: 相关信息: TaqMan® Array, Human IL-2 Pathway, Fast 96-well These 96-well plates are pre-configured with the most appropriate Taq...
参与机体的免疫作用;详述了组织损伤后IL-33/ILC2通路可被多种炎症因子激活,产生2型免疫细胞因子,从而参与组织修复和促进纤维化形成的病理生理过程;阐述了IL-33/ILC2通路与皮肤纤维化典型疾病(系统性硬化病)的临床相关性,为临床其他皮肤纤维化...
[5] Ghoreschi K, Balato A, Enerbäck C, Sabat R. Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis. Lancet. 2021;397(10275):754-766. doi:10.1016/S0140-6736(21)00184-7 [6] Huangfu L, Li R, Huang Y, Wang S...
[JAK]1/3-STAT pathway) are triggered. In T cells, and particularly Treg, phosphorylation of the IL-2Rβ chain and common γ chain by JAK1 and JAK3 and subsequent activation of STAT5 accounts for 90% of IL-2 signalling (Fig.2)[40,41]. In Treg, the PI3K-AKT-mTOR pathway is ...
[4] Bruce, A. Gregory, Peter S. Linsley, and Timothy M. Rose. "Oncostatin M." Progress in growth factor research 4.2 (1992): 157-170.[5] Yoshimura, Akihiko, et al. "Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway." The EMBO...
IL-2受体信号转导通路1. In order to study the mechanism of the interleukin-2 receptor signaling pathway in the breast cancer line and advance to reveal the primal anti-cancer effects of syk. 目的:本实验拟通过研究Syk与MDA-MB-231细胞株IL-2受体表达之间的相互影响,来探讨其相关信号转导途径,...
2. Tsukazaki H, Kaito T. The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis.International Journal of Molecular Sciences. 2020; 21(17):6401. 3. Uppala, Ranjitha et al. "Autoinflammatory psoriasis"-genetics and biology of pustular psoriasis.”Cellular & molecular immun...
IL-2 biologics have proven to be effective in preclinical studies and clinical assessment of some is now underway. These studies will soon reveal whether engineered IL-2 biologics are truly capable of harnessing the IL-2–IL-2 receptor pathway as effective monotherapies or combination therapies ...
[1] Gandhi NA, Pirozzi G, Graham NMH. Commonality of the IL-4/IL-13 pathway in atopic diseases. Expert Rev Clin Immunol. 2017;13(5):425–437. [2] Vatrella, Alessandro & Fabozzi, Immacolata & Calabrese, Cecilia & Maselli, Rosario & Pelaia, Girolamo. (2014). Dupilumab: A novel treat...