血清胰岛素样生长因子1(IGF-1)水平是生长激素轴功能判断的重要指标,年龄、性别、发育情况、不同种族、社会因素、疾病状态、营养等对IGF-1有显著影响[1,2],判断青春期孩子的IGF-1水平的升高或降低比较复杂,主要有三个方面要考虑:性别/生理年龄,...
Subjects were placed in groups to reflect different levels of physical activity: inactive (<6000 steps(.)d(-1)), somewhat active (6000-9999 steps(.)d(-1)), and regularly active (greater than or equal to10,000 steps(.)d(-1)). ANOVA was utilized to determine whether body compositi...
In children, soil-transmitted helminth infections have been linked to poor nutritional status and growth retardation in association with lower levels of IGF-1. In adults, IGF-1 has an anabolic and metabolic function and is related to nutritional status. Here, we assessed the impact of helminth ...
Technical Remark: Very low peak GH levels onprovocative testing are consistent with severe GHD, and patients with suchresults are expected to benefit greatly from GH treatment. However, thethreshold test result that distinguish...
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Growth factors important for normal brain development are low in preterm infants. This study investigated the link between growth factors and preterm brain volumes at term. Infants born <28 weeks gestational age (GA) were included. Endogenous levels o
(IgF-1) and IgF binding protein-3levels in adults with inflammatory bowel disease″,Katsanos K.H.,Tsatsoulis A.,Christdoulon D.,Challa A.,KatsarakiA.,Tsianos E.V.,Growth Horm.IgF Res.11(2001)364-367;″Insulin-like growth factor-1(IgF-1)and growth hormone(GH)in immunity and ...
IGF-1 has been linked to tumor growth in adults in a number of studies, including two large trials jointly conducted by Harvard Medical School and Brigham and Women's Hospital. A six-year study of 32,826 nurses, found that those with the highest levels of IGF-1 had a two-and-a-half...
these reagents also abrogated the neuron-promoting effects of heparin. Thus, it appears that endogenous IGF-1 may be a major regulator of stem cell differentiation into neurons. Furthermore, it was found that high levels of IGF-1 or insulin promoted the maturation and affected the neurotransmitter...
at the levels of transcription, RNA processing, and translation. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. Moreover, approximately 98% of IGF-1 is always bound to one of six binding proteins (IGF-BP). ...