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Low plasma IGF-1 levels in larger mammalian species may be physiologically significant, considering the roles of this hormone in metabolism, tissue regeneration, and cancer incidence.doi:10.1016/j.mad.2010.08.005Jeffrey A. StuartMelissa M. Page...
The aim of the present study was to investigate the effect of low-normal and high-normal levels of IGF-1 in growth hormone (GH) deficient adults on cognition and wellbeing during GH treatment. A randomized, open-label, clinical trial including 32 subjects receiving GH therapy for at least ...
Growth factors important for normal brain development are low in preterm infants. This study investigated the link between growth factors and preterm brain volumes at term. Infants born <28 weeks gestational age (GA) were included. Endogenous levels o
It is known that low levels of cIGF-1 predict the development of type 2 diabetes mellitus (DM II) and correlate with IR, increasing the risk of ischemic cardiovascular disease [7,14,15]. Mitogenic and anti-apoptotic activity of mature IGF-1, as well as different transcripts and precursor...
Short and long-term responsiveness to low dose GH in adult Growth Hormone Deficiency (GHD): role of GH receptor (GHR) polymorphism In patients with growth hormone (GH) deficiency (GHD), low doses of recombinant human GH (rhGH) have a similar or better long‐term clinical effect than hi....
In 2015, over 100 million children and 600 million adults were living with obesity worldwide4. An unfavourable deviation in the energy balance equation in favour of calorie excess results in increased adiposity and eventually ectopic deposition of lipids in tissues such as the liver and skeletal ...
Loss of core fucosylation of low-density lipoprotein receptor-related protein-1 impairs its function, leading to the upregulation of serum levels of insuli... alpha1,6-Fucosyltransferase (Fut8) catalyzes the transfer of a fucose residue from GDP-fucose to the innermost N-acetylglucosamine residue ...
Previous studies have reported that reduced levels of IGF-1 in the blood of patients with metabolic disorders are a common feature [29,30]. Furthermore, several studies have demonstrated that dysregulation and low sensitivity to insulin or IGF-1 increase the onset of AD and aggravate severe AD...
In normal condition, IGF-1R maintains low levels in the liver, but its expression will increase significantly when under pathological conditions (such as hepatitis) [57]; our results for IGF-1R verify this conclusion. Various ERS-inducers can increase the IGFBP-1 mRNA and secreted protein levels...