However, adjusting for age indicated that there was in fact no significant relationship between these two parameters. Insulin-like growth factor 1 levels did however vary significantly with patient age. Conclusions: Levels of IGF-1 showed an age-dependent variation...
Results: Although not statistically significant, the serum IGF-1 levels in infants at age 6 months were lower than those in infants at age 3 months. The IGF-1 levels showed a slow increase with age. Serum IGF-1 levels were lower in girls as compared to boys only at age 6 months. No...
The aim of the present study was to investigate the effect of low-normal and high-normal levels of IGF-1 in growth hormone (GH) deficient adults on cognition and wellbeing during GH treatment. A randomized, open-label, clinical trial including 32 subjects receiving GH therapy for at least ...
We conclude that this rhGH treatment regimen over 6 mo did not disrupt the normal growth pattern of prepubertal monkeys. Daily exposure to rhGH enhanced BW gain, CRL and IGF-1 levels. Changes in tibial length and SMS were not different from placebo controls. • 237 T Hasegawa*, P.Cohen,...
Growth factors important for normal brain development are low in preterm infants. This study investigated the link between growth factors and preterm brain volumes at term. Infants born <28 weeks gestational age (GA) were included. Endogenous levels o
IGF-1 and IGF-2 were measured by specific radioimmunoassay after acid-ethanol extraction of plasma obtained by foetoscopy from 20 normal foetuses aged 15–23 weeks. IGF-1 and IGF-2 levels were 36 ± 11 and 162 ± 55 ng/ml, respectively. In comparison, levels in cord blood were 84 ±...
Technical Remark: Very low peak GH levels onprovocative testing are consistent with severe GHD, and patients with suchresults are expected to benefit greatly from GH treatment. However, thethreshold test result that distinguish...
Low levels of IGF-1 and IGFBP-3 may result in growth retardation. Key words : insulin-like growth factor 1; insulin-like growth factor binding protein 3; small for gestational age; very low birth weight 受胎儿、孕母和环境因素的影响,出生时为小 出生体质量儿(very low birth weight infants ,...
Similarly, increased levels of IGF-I and increased IGF-I receptor expression were observed in pancreatic cancer tissue compared with normal pancreas tissue (Karna et al, 2002). It appears that IGF-I stimulation and subsequent suppression of tumour suppressor chromosome 10 (PTEN) activity enhance ...
CONCLUSION We consider IGF1/IGFBP3 molar ratio to be a useful additional parameter for assessing therapeutic safety in patients on rGH, and for maintaning the values within the normal range for age and pubertal stage.