Our study found no correlation between weight status and IGF-1 levels when adjusting for age-dependent variation. Further studies may shed light on the possible role of IGF-1 in discerning between obese children with or without increased insulin resistance.NEGREA...
In conclusion, IGF-I is a key regulator of human skin aging and declining IGF-I levels with age may play a significant role in the reduction of skin surface lipids and thickness. 展开 关键词: Insulin-like growth factor-I (IGF-I 17β-Estradiol Growth hormone (GH Progesterone Dehydro...
An age-matched group of controls (n = 24) was included. Total IGF-I and immunoreactive levels of IGFBP-3 were comparable in T(B) and controls, whereas free IGF-I (P = 0.02) in T(B) was less than in controls. Western ligand blotting (WLB)-IGFBP-3 was significantly lower in T(B...
Low levels of IGF-1 and IGFBP-3 may result in growth retardation. Key words : insulin-like growth factor 1; insulin-like growth factor binding protein 3; small for gestational age; very low birth weight 受胎儿、孕母和环境因素的影响,出生时为小 出生体质量儿(very low birth weight infants ,...
IGF-I SDS can be used to evaluate the somatotroph function, as a valid substitute to absolute IGF-I levels. Moreover, IGF-I SDS predicted the extent of hypopituitarism in adults with pituitary disease, and thus can serve as a marker of hypopituitarism severity....
Results: Although not statistically significant, the serum IGF-1 levels in infants at age 6 months were lower than those in infants at age 3 months. The IGF-1 levels showed a slow increase with age. Serum IGF-1 levels were lower in girls as compared to boys only at age 6 months. No...
The correlation between urine and serum free IGF-1 levels and age was not significant. There was also no significant relationship between free IGF-1 levels and histopathological grading. The results of this pilot study reveal that the free IGF-1 level does not help predict tumour marker in the...
Insulin-like growth factor 2 (IGF2) is a key determinant of fetal growth, and the altered expression of IGF2 is implicated in fetal growth disorders and maternal metabolic derangements including gestational diabetes. Here we studied how increased levels
The lower fasting insulin levels and the impaired β-cell function associated with IGF2BP2 SNPs are independent of obesity phenotypes. The action of these SNPs on T2D may result from an effect on β-cell function. This could lead to lower insulin levels, the association with anthropometric ...
From 3 mo of age, these concentrations were greater in male animals. Analysis of data after retrospective grouping of female calves into fast, medium and slow growth rate groups indicated different (P < 0.05) IGF-I concentrations between groups; levels were greatest in the fastest-growing...