ISG）是一类在免疫应答中受干扰素（IFN）激活后表达的基因。IFN-刺激基因集（ISG-related gene set）是指与IFN-刺激基因有关的一组基因，这些基因在IFN信号通路中发挥重要作用，参与免疫调节、炎症反应、细胞凋亡等生物学过程。ISG-related gene set在研究IFN信号通路、免疫应答及相关疾病的发病机制方面具有重要价值。
6) IFN gene 干扰素基因 1. This article reviewed research progress of IFN gene NRAMP1 gene ETEC MHC gene which are candidate gene of disease resistance pig. 作者综述了干扰素基因、NRAMP1基因、肠毒素大肠杆菌、MHC基因等候选基因的研究进展,以期为抗病育种提供借鉴。 更多例句>> 补充资料:人成纤维...
The addition of IL28B genotype information did not improve the predictive power of the 3-gene classifier.Conclusions: IL28B genotype and hepatic ISG expression are conditionally independent predictors of treatment response in CHC. There is no direct link between altered IFN位3 expression and pre-...
The HBV-encoded regulatory protein hepatitis B virus X protein (HBx) stimulates HBV gene expression from the cccDNA template; however, the mechanism by which HBx facilitates HBV replication is not clear (Keasler et al., 2007). HBx is a 154-amino-acid protein with an N-terminal negative regul...
Abstract Polyomaviruses encode a large T Ag (LT), a multifunctional protein essential for the regulation of both viral and host cell gene expression and productive viral infection. Previously, we have shown that stable expression of LT protein results in upregulation of genes involved in the IF...
We used quantitative reverse transcription-PCR (qRT-qPCR) to validate the 138 ISG candidates. Two known ISGs, IFI6 and XAF1 (Schoggins et al., 2011), were used as positive controls. Because the gene expression patterns are different in different cell lines (Fig. 1), we analyzed the mRNA...
geneINHATInterferonSignaltransductionSTATTranscriptionType I interferon (IFN) plays a crucial role in establishing the cellular antiviral state by inducing transcription of IFN-stimulated genes (ISGs). Generally, histone acetyltransferases (HATs) are positive regulators of transcription, but histone ...
Moreover, Kaposi sarcoma–associated herpesvirus (KSHV)–encoded viral FLICE inhibitory protein (vFLIP) enhances IRF4-mediated gene induction. Coexpression of IRF4 with vFLIP significantly increased ISG60 (IFIT3) and Cig5 (RSAD2) transcription that was dependent on the ability of vFLIP to ...
Mechanistically, the loss of PRKAR2A inmice resulted in an increased IFN-stimulated gene (ISG) expression and altered gut microbiota. Inhibition of ISGs partially reversed the protective effects against DSS-induced colitis inmice. Antibiotic treatment and cross-fostering experiments demonstrated that the...
Example gene set containing IFN stimulated genesvarious