IFN-刺激基因（IFN-stimulated genes，ISG）是一类在免疫应答中受干扰素（IFN）激活后表达的基因。IFN-刺激基因集（ISG-related gene set）是指与IFN-刺激基因有关的一组基因，这些基因在IFN信号通路中发挥重要作用，参与免疫调节、炎症反应、细胞凋亡等生物学过程。ISG-related gene set在研究IFN信号通路、免疫应答及...
The alternation of the interferon stimulated genes(ISGs) expression profile was analysed by real-time PCR and microarray assay. 方法在A549人肺癌细胞株中应用基因转染技术研究5个不同的FLJ20420 siRNA对FLJ20420基因沉默情况;应用real-time PCR和基因芯片技术相结合,分别检测经2个不同FLJ20420-siRNA干扰后A549...
4 reagents referenced in Simian virus 40 large T antigen induces IFN-stimulated genes through ATR kinase.
i型ifn(ifn-α和ifn-β)主要以抗病毒为主,通过相关信号通路诱导多种干扰素激活基因(ifn-stimulatedgene,isgs)表达,从而发挥抗病毒的作用。ii型干扰素(ifn-γ)是抑制弓形虫增殖的重要的细胞因子。弓形虫速殖子侵入机体后,刺激巨噬细胞产生il-12,进而激活nk细胞和t细胞,使之分泌ifn-γ。ifn-γ随之诱导ifn-γ-induci...
Moreover, TNF-??- and IFN??/IFN??-dependent effects on C2C12 myotubes were associated with increased activity of Atrogin1 and MuRF1 genes, which code ubiquitin ligases. MyHC IIa gene activity was unaltered by cytokines. Inhibition of NF-??B or JAK/STAT with specific metabolic inhibitors ...
Virus infection induces the production of type I interferons (IFNs). IFNs bind to their heterodimeric receptors to initiate downstream cascade of signaling