IFN-刺激基因（IFN-stimulated genes，ISG）是一类在免疫应答中受干扰素（IFN）激活后表达的基因。IFN-刺激基因集（ISG-related gene set）是指与IFN-刺激基因有关的一组基因，这些基因在IFN信号通路中发挥重要作用，参与免疫调节、炎症反应、细胞凋亡等生物学过程。ISG-related gene set在研究IFN信号通路、免疫应答及...
1) IFN-stimulated genes (ISG) 干扰素激活相关基因2) ISGs 干扰素激活基因 1. The alternation of the interferon stimulated genes(ISGs) expression profile was analysed by real-time PCR and microarray assay. 方法在A549人肺癌细胞株中应用基因转染技术研究5个不同的FLJ20420 siRNA对FLJ20420基因沉默情况;...
Interferon (IFN)-stimulated genes (ISGs) as a resistance mechanism in cancer cell deathLipid raftsAdrenergic receptorGPCRSignal transductionPreassembled receptor/G protein complexesMass spectrometry is becoming a more and more powerful tool for investigating protein complexes. Recent developments, based on ...
To understand the molecular mechanisms that mediate the anti-hepatitis B virus (HBV) effect of interferon (IFN) therapy, we conduct high-throughput bimolecular fluorescence complementation screening to identify potential physical interactions between the HBx protein and 145 IFN-stimulated genes (ISGs). ...
we focus on the cellular signaling mechanism that leads to the induction of IFN responses by LT. Our results show that ectopic expression of SV40 LT results in the induction of IFN-stimulated genes (ISGs) in human fibroblasts and confers an antiviral state. We describe a LT-initiated DNA d...
Silent hypoxia has emerged as a unique feature of coronavirus disease 2019 (COVID-19). In this study, we show that mucins are accumulated in the bronchoalveolar lavage fluid (BALF) of COVID-19 patients and are upregulated in the lungs of severe respirato
(GSEA) was performed to identify pathways in the Kyoto Encyclopedia of Genes and Genomes (KEGG) database that were influenced by NOD. Enlisted in Fig.4Ais a selection of pathways that are down-regulated when endothelial cells were stimulated with IFNγ in the presence of NOD. Based on an ...
Moreover, TNF-??- and IFN??/IFN??-dependent effects on C2C12 myotubes were associated with increased activity of Atrogin1 and MuRF1 genes, which code ubiquitin ligases. MyHC IIa gene activity was unaltered by cytokines. Inhibition of NF-??B or JAK/STAT with specific metabolic inhibitors ...
Expression of β-Defensin Genes in Bovine Alveolar Macrophages Bovine alveolar macrophages (BAM) were examined for the expression of beta-defensins and to determine whether their expression could be upregulated by bact... LK Ryan,J Rhodes,M Bhat,... - 《Infection & Immunity》 被引量: 204发表...
(MAPKs), and the activation of nuclear NF-κB.Our results indicate that Xanthoceraside exhibits anti-inflammatory properties by suppressing the transcription of inflammatory mediator genes through the MAPKs and NF-KB signaling pathways.The anti-inflammatory properties of Xanthoceraside may make it ...