1) IFN-stimulated genes (ISG) 干扰素激活相关基因2) ISGs 干扰素激活基因 1. The alternation of the interferon stimulated genes(ISGs) expression profile was analysed by real-time PCR and microarray assay. 方法在A549人肺癌细胞株中应用基因转染技术研究5个不同的FLJ20420 siRNA对FLJ20420基因沉默情况;...
IFN-β 主要由成纤维细胞产生。I型IFN主要通过与细胞表面的I型IFN受体 (IFNAR) 结合发挥作用,激活JAK-STAT信号通路,诱导数百个干扰素刺激基因 (Interferon-Stimulated Genes, ISGs) 的表达。这些ISGs编码具有多种抗病毒活性的蛋白质,例如蛋白激酶R (PKR)、2'-5'寡腺苷酸合成酶 (2'-5' oligoadenylate synthetase,...
JAK),活化的 JAK 催化结合在受体上的信号传导及转录激活因子 1(Signal Transducer and Activator of Transcription 1,STAT1)蛋白发生磷酸化,磷酸化 STAT1(p-STAT1)以同源二聚体形式进入细胞核,结合到 IFN-γ 激活序列(GAS)位点上,激活干扰素刺激基因 (Interferon-stimulated Genes,ISGs)大量转录[18, 19]。
Interferon (IFN)-stimulated genes (ISGs) as a resistance mechanism in cancer cell deathLipid raftsAdrenergic receptorGPCRSignal transductionPreassembled receptor/G protein complexesMass spectrometry is becoming a more and more powerful tool for investigating protein complexes. Recent developments, based on ...
此外,干扰素治疗的副作用大,是影响其广泛使用的重要原因之一。因此,研究其下游的IFN刺激基因(IFN-stimulated genes, ISGs)的抗病毒作用及机制,对了解宿主IFNs介导的固有免疫的抗病毒机制及提供抗乙型肝炎病毒(hepatitis B virus, HBV)治疗药物新靶点的选择具有重要意义。
此外,干扰素治疗的副作用大,是影响其广泛使用的重要原因之一。因此,研究其下游的IFN刺激基因(IFN-stimulated genes, ISGs)的抗病毒作用及机制,对了解宿主IFNs介导的固有免疫的抗病毒机制及提供抗乙型肝炎病毒(hepatitis B virus, HBV)治疗药物新靶点的选择具有重要意义。
Treatment of cells with interferons (IFNs) induces the phosphorylation of signal transducer and activator of transcription 1 (STAT1), leading to the expression of hundreds of IFN-stimulated genes (ISGs). ISGs exert various antiviral and pro-inflammatory reactions. We have previously reported that ...
I 型干扰素与其受体相互作用 , 活化 JAK (Janus kinase) 和 STAT (Signaltransducers and activators of transcription)信号通路 , 诱导IFN-stimulated genes (ISGs)的表达,这些ISGs协同作用,激活机体的抗病毒反应。尽管,I型干扰素在机体的清除病毒反应中起着非常重要的作用,但是异常的I 型干扰素的产生 , 会引发各种...
(RSp14; 16 of 260 single-replicate stains).fThe expression of IFN-stimulated genes (ISGs) was measured by RNA-seq in PBMCs at 2 h post-rIFNα and was calculated as a log2fold-change between rIFNα-treated (n = 6) and control RMs (n = 5), which is represented as ...
Owing to ongoing recognition of pathogen-associated molecular patterns, immune activation and upregulation of IFN-stimulated genes (ISGs) are sustained in the chronically infected host. Albeit most ISGs are important effectors for containing viral replication, some might exert compensatory immune suppression...