ifn-stimulated genes相关基因集 IFN-刺激基因（IFN-stimulated genes，ISG）是一类在免疫应答中受干扰素（IFN）激活后表达的基因。IFN-刺激基因集（ISG-related gene set）是指与IFN-刺激基因有关的一组基因，这些基因在IFN信号通路中发挥重要作用，参与免疫调节、炎症反应、细胞凋亡等生物学过程。ISG-related gene ...
1) IFN-stimulated genes (ISG) 干扰素激活相关基因2) ISGs 干扰素激活基因 1. The alternation of the interferon stimulated genes(ISGs) expression profile was analysed by real-time PCR and microarray assay. 方法在A549人肺癌细胞株中应用基因转染技术研究5个不同的FLJ20420 siRNA对FLJ20420基因沉默情况;...
Interferon (IFN)-stimulated genes (ISGs) as a resistance mechanism in cancer cell deathLipid raftsAdrenergic receptorGPCRSignal transductionPreassembled receptor/G protein complexesMass spectrometry is becoming a more and more powerful tool for investigating protein complexes. Recent developments, based on ...
因此,研究其下游的IFN刺激基因(IFN-stimulated genes, ISGs)的抗病毒作用及机制,对了解宿主IFNs介导的固有免疫的抗病毒机制及提供抗乙型肝炎病毒(hepatitis B virus, HBV)治疗药物新靶点的选择具有重要意义。 2022年9月7日,北京大学基础医学院庄辉/李彤/向宽辉团队在Antiviral Research杂志上发表了题为“TRIM56 impai...
此外,干扰素治疗的副作用大,是影响其广泛使用的重要原因之一。因此,研究其下游的IFN刺激基因(IFN-stimulated genes, ISGs)的抗病毒作用及机制,对了解宿主IFNs介导的固有免疫的抗病毒机制及提供抗乙型肝炎病毒(hepatitis B virus, HBV)治疗药物新靶点的选择具有重要意义。
To understand the molecular mechanisms that mediate the anti-hepatitis B virus (HBV) effect of interferon (IFN) therapy, we conduct high-throughput bimolecular fluorescence complementation screening to identify potential physical interactions between the HBx protein and 145 IFN-stimulated genes (ISGs). ...
I 型干扰素与其受体相互作用 , 活化 JAK (Janus kinase) 和 STAT (Signaltransducers and activators of transcription)信号通路 , 诱导IFN-stimulated genes (ISGs)的表达,这些ISGs协同作用,激活机体的抗病毒反应。尽管,I型干扰素在机体的清除病毒反应中起着非常重要的作用,但是异常的I 型干扰素的产生 , 会引发各种...
The specificity of interferon effectors across an expanded range of viruses is studied, with results indicating that positive-sense single-stranded RNA viruses are more susceptible to interferon-stimulated gene activity than negative-sense RNA or DNA vir
4 reagents referenced in Simian virus 40 large T antigen induces IFN-stimulated genes through ATR kinase.
DCs produce type I IFNs to different classes of pathogens. While type I IFN responses are essential in antiviral immunity through the induction of antiviral effector molecules encoded by IFN-stimulated genes (ISGs)20, their role in fungal infections is still unknown.Candida albicansstimulation of...