ifn-stimulated genes相关基因集 IFN-刺激基因（IFN-stimulated genes，ISG）是一类在免疫应答中受干扰素（IFN）激活后表达的基因。IFN-刺激基因集（ISG-related gene set）是指与IFN-刺激基因有关的一组基因，这些基因在IFN信号通路中发挥重要作用，参与免疫调节、炎症反应、细胞凋亡等生物学过程。ISG-related gene ...
1) IFN-stimulated genes (ISG) 干扰素激活相关基因2) ISGs 干扰素激活基因 1. The alternation of the interferon stimulated genes(ISGs) expression profile was analysed by real-time PCR and microarray assay. 方法在A549人肺癌细胞株中应用基因转染技术研究5个不同的FLJ20420 siRNA对FLJ20420基因沉默情况;...
We investigated if the IL28B genotype determines the constitutive expression of IFN stimulated genes (ISGs) in the liver of patients with CHC.Methods: We genotyped 93 patients with CHC for 3 IL28B single nucleotide polymorphisms (SNPs, rs12979860, rs8099917, rs12980275), extracted RNA from ...
因此,研究其下游的IFN刺激基因(IFN-stimulated genes, ISGs)的抗病毒作用及机制,对了解宿主IFNs介导的固有免疫的抗病毒机制及提供抗乙型肝炎病毒(hepatitis B virus, HBV)治疗药物新靶点的选择具有重要意义。 2022年9月7日,北京大学基础医学院庄辉/李彤/向宽辉团队在Antiviral Research杂志上发表了题为“TRIM56 impai...
Owing to ongoing recognition of pathogen-associated molecular patterns, immune activation and upregulation of IFN-stimulated genes (ISGs) are sustained in the chronically infected host. Albeit most ISGs are important effectors for containing viral replication, some might exert compensatory immune suppression...
( 2005 ). Upregulation of the IFN-gamma-stimulated genes in the development of delayed pigmented spots on the dorsal skin of F1 mice of HR-1 x HR/De . J. Invest. Dermatol. 124 , 1053 – 1061 .Aoki H., Moro O. Upregulation of the IFN-γ-stimulated genes in the development of ...
I 型干扰素与其受体相互作用 , 活化 JAK (Janus kinase) 和 STAT (Signaltransducers and activators of transcription)信号通路 , 诱导IFN-stimulated genes (ISGs)的表达,这些ISGs协同作用,激活机体的抗病毒反应。尽管,I型干扰素在机体的清除病毒反应中起着非常重要的作用,但是异常的I 型干扰素的产生 , 会引发各种...
DCs produce type I IFNs to different classes of pathogens. While type I IFN responses are essential in antiviral immunity through the induction of antiviral effector molecules encoded by IFN-stimulated genes (ISGs)20, their role in fungal infections is still unknown.Candida albicansstimulation of...
To understand the molecular mechanisms that mediate the anti-hepatitis B virus (HBV) effect of interferon (IFN) therapy, we conduct high-throughput bimolecular fluorescence complementation screening to identify potential physical interactions between the HBx protein and 145 IFN-stimulated genes (ISGs). ...
Type I IFNs are produced upon viral infection, leading to the modulation of IFN-stimulated genes (ISGs) via type I IFN receptors, IFNAR1 and IFNAR29. In placental mammals, type I IFNs contains a few subtypes, including IFN-α, IFN-β, IFN-δ, IFN-ε, IFN-ζ, IFN-κ, IFN-μ, ...