Moreover, we unraveled host CD95 as one of the target genes of miR-431-5p and miR-431-5p impeded virus replication by targeting CD95 mRNA and the downregulation of CD95 resulted in the activation of NF-kB, leading to the inhibition of viral replication. The present study provides ...
IFNs bind to their heterodimeric receptors to initiate downstream cascade of signaling, leading to the up-regulation of interferon-stimulated genes (ISGs). ISGs play very important roles in innate immunity through a variety of mechanisms. Although hundreds of ISGs have been identified, it is ...
Overall, the results are considered robust because 128 of the compiled, curated list of 193 regulated genes were detected by two, or more, of the technologies.Introduction The interferon (IFN) response is one of the most important arms of host innate immunity against virus infection [1, 2]....
We have previously reported that N-octanoyl dopamine (NOD) inhibits TNFα mediated gene expression in endothelial cells through the inhibition of a subset of nuclear factor kappa B (NFκB)-regulated genes21. NOD also transiently inhibits T-cell proliferation, albeit that early T-cell receptor sign...
addShow full affiliation list * Authors to whom correspondence should be addressed. † These authors contributed equally to this work. Submission received: 9 June 2022/Revised: 14 August 2022/Accepted: 24 August 2022/Published: 30 August 2022 ...