Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature 2014, 505, 691-695. [CrossRef] [PubMed]Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy ...
The type I interferon (IFN) response protects cells from viral infection by inducing hundreds of interferon-stimulated genes (ISGs), some of which encode direct antiviral effectors1,2,3. Recent screening studies have begun to catalogue ISGs with antiviral activity against several RNA and DNA viruses...
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.: The type I interferon (IFN) response protects cells from viral infect
The type I interferon (IFN) response protects cells from viral infection by inducing hundreds of interferon-stimulated genes (ISGs), some of which encode direct antiviral effectors1,2,3. Recent screening studies have begun to catalogue ISGs with antiviral activity against several RNA and DNA viruses...
MiR-302d is a member of the miR-302 family of miRNAs, a family which have been demonstrated to target a variety of genes including interleukin-1 receptor-associated kinase 4 (IRAK4) [17], altered expression of which can lead to dysregulation of key cellular responses. In addition to these...
Interestingly, real-time PCR analysis showed that IFN-γ-inducible genes (IIGs) were differentially affected by GC, with CXCL10 being GC sensitive and CXCL11 and IFIT2 being GC insensitive. Further investigation showed that the differential sensitivity of IIGs to GC was due to their variable ...
Stat1 alpha expression is involved in IFN-gamma induction of the class II transactivator and class II MHC genes. Class II MHC Ags are critical in the regulation of immune responses by presenting Ag to T lymphocytes, resulting in their activation and differentiation. C... YJ Lee,EN Benveniste ...
183]. The human Papillomavirus-16 (HPV-16) expresses the viral E7 protein that binds the p48 protein blocking its translocation to the nucleus, impeding the association of IRF-9 with the STAT-1/STAT-2 heterodimer (ISGF3), and thereby inhibiting the induction of IFN-I inducible genes [184...
Furthermore, evidence exists that IFN-induced genes are upregulated in persistently BVDV infected animals18–21. Yet, no factors protecting the virus against effectors of the IFN-system – apart from the utilization of IRES mediated translation initiation, which should render the virus independent of...
SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state. Transcription factors that play key roles in regulating embryonic stem (ES) cell state have been identified, but the chromatin regulators that help maintai... Bilodeau,Steve,Kagey,... - 《...