Cancer Gene TherapyHashimoto, H., Ueda, R., Narumi, K., Heike, Y., Yoshida, T., Aoki, K. (2014) Type I IFN gene delivery suppresses regulatory T cells within tumors. Cancer Gene Ther. 21, 532-541.Hashimoto H, Ueda R, Narumi K, Heike Y, Yoshida T, Aoki K (2014) Type I ...
But, a puzzling question remains to be answered, as to how intronless type I IFN genes in amniotes might have evolved from intron-containing type I IFN genes in fish and amphibians. In this study, intronless and intron-containing type I IFNs were found in the amphibian model, Xenopus ...
•Intronless and intron-containing type I IFN genes coexist inXenopus tropicalis.•Intronless and intron-containing IFNs phylogenetically divide into three and two subgroups respectively.•Different gene expression patterns were observed among subgroups of IFNs.•Retroposition might have occurred in...
type I IFN HBV HBx TRIM5γ TRIM31 Introduction Chronic hepatitis B virus (HBV) infection remains a major public health threat. It is associated with increasing rates of hepatocellular carcinoma (HCC) worldwide. According to the World Health Organization (WHO), 2 billion people are infected with...
To understand the molecular mechanisms that mediate the anti-hepatitis B virus (HBV) effect of interferon (IFN) therapy, we conduct high-throughput bimolecular fluorescence complementation screening to identify potential physical interactions between the HBx protein and 145 IFN-stimulated genes (ISGs). ...
Transient expression of a type I interferon (IFN)-inducible gene signature is a risk factor for autoimmunity in children genetically predisposed to develop type 1 diabetes mellitus (T1DM). Microarray analysis was used to define a set of 225 IFN-inducible genes, the expression of which was ...
Upon recognition of viral components by pattern recognition receptors, including TLRs and retinoic acid-inducible gene I-like helicases, cells are activated to produce type I IFN, which plays key roles in host antiviral innate immune response. However, excessive IFN production may induce immune disor...
et al. Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory. J. Immunol. 183, 1695–1704 (2009). CAS PubMed PubMed Central Google Scholar Marshall, H. D., Prince, A. L., Berg, L. J. & Welsh, R. M. ...
Microarray analysis found that of the endogenous type I IFN-regulated genes specific to either BMM or GM-BMM, 488 of these gene alterations were unique to BMM, while only 50 were unique to GM-BMM. Moreover, BMM displayed enhanced basal mRNA levels, relative to GM-BMM, of a number of ...
Type I IFN innate immune response to adenovirus-mediated IFN-gamma gene transfer contributes to the regression of cutaneous lymphomas. J Clin Invest. 2007; 117 (10):2834–2846.Urosevic M, Fujii K, Calmels B, Laine E, Kobert N, et al. (2007) Type I IFN innate immune response to ...