ISG15、USP18及MxA通路蛋白皮肌炎本质上属于一种自身免疫性疾病,主要是由于免疫功能紊乱而导致的.通常情况下,主要表现为对称性四肢近端肌无力,与此同时,还可能出现骨骼肌以及皮肤损害的情况.近年来研究发现,Ⅰ型干扰素介导的相关信号通路在皮肌炎的发病中具有重要意义,其中以ISG15,USP18及MxA通路蛋白的表达在皮肌炎发病...
病毒（如HSV-1）可以编码多种蛋白逃逸宿主IFN的产生，那病毒逃逸ISG的意义在哪里？ 它为啥要对ISG下手...
1) IFN-stimulated genes (ISG) 干扰素激活相关基因2) ISGs 干扰素激活基因 1. The alternation of the interferon stimulated genes(ISGs) expression profile was analysed by real-time PCR and microarray assay. 方法在A549人肺癌细胞株中应用基因转染技术研究5个不同的FLJ20420 siRNA对FLJ20420基因沉默情况;...
ISG15 ubiquitin-like modifier (ISG15) is a ubiquitin-like protein transcriptionally regulated by IFN-?? which shows antivirus and antitumor activities. However, the exact role of ISG15 is unknown. In the present study, we showed that IFN-?? significantly induced ISG15 expression but failed to...
3、第一方面,本发明提供isg15-(h4)2-ifn-λ3重组蛋白,所述isg15-(h4)2-ifn-λ3重组蛋白通过连接肽(h4)2将isg15与ifn-λ3连接起来,所述isg15-(h4)2-ifn-λ3重组蛋白具有如seq id no:1所示的氨基酸序列。 4、第二方面,提供多核苷酸,所述多核苷酸编码本发明所述的isg15-(h4)2-ifn-λ3重组蛋白,所...
“RXR在筛选Ifnβ,Isg15,Gbp-1,Oas2,Irf7,Isg20,Ifn4激动剂中的用途”专利由田晓丽、 李卫东共同发明。本发明涉及生物医药领域,特别是涉及RXR在筛选Ifnβ,Isg15,Gbp-1,Oas2,Irf7,Isg20,Ifn4激动剂中的用途。钛学术提供该文献下载服务。
Imaizumi T;Yoshida H;Hayakari R;.Interferon-stimulated gene (ISG)60,as well as 1SG56 and ISG54,positively regulates TLR3/IFN-β/STAT1 axis in U373MG human astrocytoma cells.Neurosci Res.2016.35-41Imaizumi T, Yoshida H, Hayakari R, Xing F, Wang L, Matsumiya T, Tanji K, Kawaguchi S,...
Inherited ISG15 deficiency, however, has manifested with two distinct presentations to date: susceptibility to mycobacterial disease and intracranial calcifications from hypomorphic interferon-II (IFN-II) production and excessive IFN-I response, respectively. Accordingly, these patients were managed for ...
ISG15是I型干扰素(IFN)诱导的基因,编码具有多效功能的蛋白质,既充当可溶性分子又充当蛋白质修饰剂。ISG15参与称为ISGylation的过程,其修饰底物至少有150种蛋白质,并介导包括例如NF-κB、JNK和IRF-3信号传导等信号通路。ISG15也以游离形式存在,在细胞内或细胞外发挥作用。体外和体内证据均表明,游离ISG15在几种细胞...
RAW-Lucia™ ISG cells are responsive to murine IFN-α and IFN-β but do not respond to their human counterparts. They are also responsive to PRR ligands that trigger the IFN signaling pathway, including CDS ligands, such astransfected double-stranded DNA, RIG-I ligands, such astransfected ...