同时 GSK3β 抑制剂降低了sEHiΔMyh6心肌细胞中TBK1 和 GSK3β 的磷酸化。Collectively, these data indicate that EETs exert a cardioprotective effect during CVB3 infection through a GSK3β-dependent signaling cascade involving the type I IFN pathway....
Background The purpose of this study was to study the effect of STING-IFN-I pathway on incision induced postoperative pain in rats and its possible mechanisms.Methods The pain thresholds were evaluated by measuring the mechanical withdrawal threshold and the thermal withdrawal latency. The satellite ...
Huyghe L et al. Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies. EMBO Mol Med. 2020 Feb 7;12(2):e11223. Gao J et al. Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of...
具体来说,肿瘤的IFN信号通过两种方式发挥免疫抑制的作用:第一,肿瘤IFN感应能够上调经典的第一类主要组织相容性复合体(MHC-I)抑制自然杀伤(NK)细胞;第二,肿瘤IFN感应通过上调非经典的MHC-I类分子Qa-1b抑制CD8+T细胞。 要知道,大量的研究表明IFN-γ在肿瘤的免疫监视中发挥重要作用[2-4]。这一发现可以说颠覆了我们...
Gao, J. et al. Loss of IFN-γ pathway genes in tumor cells as a mechanism of resistance to anti-CTLA-4 therapy. Cell 167, 397–404.e9 (2016) Benci, J. L. et al. Opposing functions of interferon coordinate adaptive and innate immune responses to cancer immune ...
Gao J et al. Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy. Cell. 2016 Oct 6;167(2):397-404.e9.
Gao J et al. Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy. Cell. 2016 Oct 6;167(2):397-404.e9.
Gao, J. et al. Loss of IFN-γ pathway genes in tumor cells as a mechanism of resistance to anti-CTLA-4 therapy. Cell 167, 397–404.e9 (2016) Benci, J. L. et al. Opposing functions of interferon coordinate adaptive and innate immune responses to cancer immune checkpoint blockade. Cell...
Objective: This study aimed to investigate mitochondrial changes and the mitochondrial antiviral-signaling protein (MAVS)-type I interferon (IFN1) signaling pathway in the muscles of anti-melanoma differentiation gene 5(MDA5) dermatomyositis (DM) patients. ...
Key interferon (IFN) cell signaling pathway targets Two subtypes of IFN comprise the IFN family of cytokines: Type I IFN (IFNAR) Over 20 variants identified, including IFNα and IFNβ. All share the ability to bind to IFNAR receptors. ...