Human Anti-IFN-gamma Neutralizing Antibodies as Selective IFN-gamma Pathway InhibitorsThis invention provides antibodies that interact with or bind to human interferon-gamma (IFN-γ) and methods for treating IFN-γ mediated diseases by administering a pharmaceutically effective amount of antibodies to ...
Loss of IFN-gamma pathway genes in tumor cells as a mechanism of resistance to anti- CTLA-4 therapy. Cell (2016) 167(2):397-404 e9. doi:10.1016... J Gao,LZ Shi,H Zhao,... - 《Cell》 被引量: 159发表: 2016年 221 CRISPR screen identifies loss of IFNγR signaling and downstream...
The cytokine interferon gamma (IFN-γ) stimulates neopterin release and tryptophan degradation into kynurenines through the kynurenine pathway. High le
IFN-gamma 产品 信息 英文名称 : Interferon gamma 中文名称 :干扰素 -γ 靶点别称 : IFNG , IFN-Gamma , Interferon-γ 物种: Human / Mouse 属性: Protein / Antibody / Kits 标记: Biotin-labeled / Unconjugate
Albamunits V, Quintana F, Reshef T, Elias D and Cohen I R 1999 Acceleration of autoimmune diabetes by cyclophosphamide is associated with enhanced IFN-g secretion pathway; J Autoimmun. 13 383–392Ablamunits V, Quintana F, Reshef T, Elias D, Cohen IR. Acceleration of autoimmune diabetes by ...
NO release and cytotoxic activity are inhibited by N-monomethyl-L-arginine (L-NMMA), a specific inhibitor of the NO pathway and increased by L-arginine, an NO precursor, and tetrahydrobiopterin (BH4), a nitric oxide synthase (NOS) cofactor. Our results indicate that IFN-gamma mediated iNOS ...
The cellular responses to both cytokines are activated via the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. During the past 10 years, the crosstalk mechanism between the ...
Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated ...
To understand JAK1 and JAK2 involvement in MM resistance to NK cells, we undertook a series of experiments to analyze the JAK signaling pathway in MM cells. We first analyzed the activation status of STAT proteins in a series of MM cell lines (IM-9, KM12BM, RPMI 8226, U266) in which...
Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated ...