Djuran, M. I., et al., " Hydrolysis of amide bond in histidine-containing peptides promoted by chelated amino acid palladium(II) complexes: dependence of hydrolytic pathway on the coordination modes of the peptides ", Polyhedron, 18(27), (Sep. 14, 1999), 3611-3616....
Moreover, all the above mentioned Pd(II) complexes were also able to catalyze the regioselective hydrolysis of the His–Gly amide bond of Ac–L–His–Gly dipeptide. However, in the reaction with Ac–L–His–Gly, only Pt(II) aqua complexes containing bridging ligands with two nitrogen atoms...
Biochemical information regarding the mechanism of bond hydrolysis offers insight into the possible chemical groups in the enzyme active site responsible for hydrolysis. Assuming that these groups have a relatively fixed geometry in accord with their functional role, then their three-dimensional position ...
In the presence of equimolar amounts of amines or amino acid derivatives, 2 reacts in H 2 O without condensing agents to form a new peptide bond.doi:10.1016/S0040-4039(97)00330-4J.William SuggsRichard M. PiresTetrahedron LettersSuggs et al., " Facile Hydrolysis and Formation of Amide ...
HYDROLYSIS OF AMIDE GROUP
which undergoes substantial metabolismin vivowith hydrolysis of the amide bond liberating 3-trifluoromethyl-4-nitroaniline. This aniline has been detected in the plasma of patients after oral administration of the drug5and exposure has been associated with hepatotoxicity2. By contrast, the structurally-...
Alright. Next, we're going to have yet another proton transfer where this sulfur is going to deprotonate this OH. Oxygen holds on to the electrons, so then we're going to get this neutral amide plus this thiol. Now remember, because of the acidity ...
PURPOSE:To facilitate the hydrolysis of a glycylamide bond existing in a hydrophobic solid and stable in normal state, by converting the bond to quaternary ammonium with ethylene oxide or propylene oxide. CONSTITUTION:A glycylamide group of formula I (R1, R3, R5 are H or lower alkyl; R2 and...
IntroductionEnantioselective Hydrolysis of Carboxylic Acid AmidesEnantioselective Hydrolysis of Cyclic AmidesEnantioselective Hydrolysis of Amino Acid AmidesEnantioselective Hydrolysis of Hydroxy Acid AmidesEnantioselective Hydrolysis of Azido Acid AmidesSelective Cleavage of a C-Terminal Amide BondSummary and OutlookRe...
2022,International Journal of Biological Macromolecules WenqiWang, ...YonggangLiu 2.1Enzymatic hydrolysis Enzymatic hydrolysisis the use of specificenzymesto hydrolyze theamidebonds in specific parts of the protein to form different fragments ofpolypeptides. It's a common method for preparing active polype...