US4393174 * Nov 9, 1981 Jul 12, 1983 Dynapol Base hydrolysis of pendant amide polymersUS4393174 * 1981年11月9日 1983年7月12日 Dynapol Base hydrolysis of pendant amide polymersDawson D J, Brock P J. Base hydrolysis of pendant amide polymers [P]. U. S. Patent 4 393 174, 1983....
ChemInform Abstract: Theoretical Study of Base-Catalyzed Amide Hydrolysis: Gas and Aqueous-Phase Hydrolysis of Formamidesolvolysis, hydrolysisgeneral, theoretical studiesChemInform is a weeklying Service, delivering concise information at a glance that was extracted from about 100 leading journals. To ...
The characteristic reaction of covalent amides ishydrolysis(a chemical reaction with water), by which they are converted to acids and amines; this reaction ordinarily is slow unless it is catalyzed by a strong acid, an alkali, or an enzyme. Amides also can be dehydrated to nitriles. Why is ...
HDAC8 is a metal-dependent class I HDAC and is proposed to use a general acid-base catalytic pair in the mechanism of amide bond hydrolysis. Here, we report site-directed mutagenesis and enzymological measurements to elucidate the catalytic mechanism of HDAC8. Specifically, we focus on the ...
Therefore, N-Mannich bases prodrugs could be an excellent strategy to enhance the delivery of the active compound due to the enhancement in water solubility as well as enhancement in lipophilicity. The rate of hydrolysis of N-Mannich bases is the same in plasma and in buffer since its ...
The properties of the transition state for serine protease-catalyzed hydrolysis of an amide bond were determined for a series of subtilisin variants from B... RR Bott,G Chan,B Domingo,... - 《Biochemistry》 被引量: 27发表: 2003年 Mechanism of hydrolysis of a thiazolium ion: General acid-...
Is bicarbonate of soda an acid or base? Write a base (NaOH) hydrolysis reaction for (a) Hexanoic acid, (b) Methyl hexanoate, and (c) N-methyl Butanamide. When titrating acids and bases (Weak or strong), how do you determine whether you use H2O o...
They are produced from the enzyme-mediated hydrolysis of cornstarch. Cyclodextrins having less than six glucose units are not formed owing to stoichiometric reasons, whereas cyclodextrins having more than eight units of glucose show weak complexing ability with drugs. There are three cyclodextrins ...
Effect of N-methylation of 2-carbamoylphenyl mesitoate upon the ability of the amide group to promote cleavage of the ester linkage and upon the susceptibility to hydrolysis of the imide intermediate The great difference in reactivity of the two imides is shown to support a mechanism for hydrolys...
A simple, efficient procedure for the conversion of phenylhydrazine to 1-alkyl-1-phenylhydrazines via base-promoted hydrolysis of 1-alkyl-3-amino-4,5-dihydro-1-phenyl-1H-pyrazolium iodides (2) is described. N1, N1-disubstituted hydrazones of trans-cinnamamide and acrylamide are obtained by ...