Proximity effect on the general base catalysed hydrolysis of amide linkage: The role of cationic surfactant, CTABr2-Hydroxybenzamideskineticsmicellar effectThe bis phenoxide forms of (1,2) bis (2-hydroxybenzamido)ethane( I ), (1,5) bis (2-hydroxybenzamido)3-azapentane( II ), (1,3) ...
ChemInform Abstract: Theoretical Study of Base-Catalyzed Amide Hydrolysis: Gas and Aqueous-Phase Hydrolysis of FormamideChemInform Abstract: Theoretical Study of Base-Catalyzed Amide Hydrolysis: Gas and Aqueous-Phase Hydrolysis of Formamidesolvolysis, hydrolysisgeneral...
The properties of the transition state for serine protease-catalyzed hydrolysis of an amide bond were determined for a series of subtilisin variants from B... RR Bott,G Chan,B Domingo,... - 《Biochemistry》 被引量: 27发表: 2003年 Mechanism of hydrolysis of a thiazolium ion: General acid-...
The characteristic reaction of covalent amides ishydrolysis(a chemical reaction with water), by which they are converted to acids and amines; this reaction ordinarily is slow unless it is catalyzed by a strong acid, an alkali, or an enzyme. Amides also can be dehydrated to nitriles. Why is ...
Effect of N-methylation of 2-carbamoylphenyl mesitoate upon the ability of the amide group to promote cleavage of the ester linkage and upon the susceptibility to hydrolysis of the imide intermediate The great difference in reactivity of the two imides is shown to support a mechanism for hydrolys...
Therefore, N-Mannich bases prodrugs could be an excellent strategy to enhance the delivery of the active compound due to the enhancement in water solubility as well as enhancement in lipophilicity. The rate of hydrolysis of N-Mannich bases is the same in plasma and in buffer since its ...
Figure 2. Several carboxylic acids enhance C-to-U RNA editing catalyzed by recombinant KP6. Relative C-to-U RNA editing was assayed in reactions with 2 mM additions of 20 different carboxylic acids. Percent editing was calculated from three reactions per treatment. Calculated values were then re...
3-phosphate dehydrogenase.15,16 The stereospecific formation of the tricyclic pentalenene precursor is critical for the antibacterial activity of pentalenolactone, and the three fused rings and four stereocenters of pentalenene are precisely generated in a single reaction catalyzed by pentalenene synthase....
enabling the formation of mono-, di-, or multinuclear complexes [1,2]. Moreover, the active electron pair on these heteroatoms significantly contributes to the bonding in metal–ligand interactions. Schiff bases, distinguished by the existence of an azomethine moiety, are known for their ability ...
Pb2+, Zn2+, and to some extent Mg2+ also display rate acceleration over the uncatalyzed reaction (Breslow and Huang, 1991). In general, cations with a low pKa of their hydrates (Table 5.1) cleave RNA better than cations with a high pKa. This is consistent with the proposal (Brown et...