amide hydrolysis in the dry statedeamidationdesmopressinisotachophoresisside reactionThe hydrolysis of peptide-amides in the solid state at 4掳 due to the presence of residual strong acid was investigated. It was found that even small molar excesses of these acids cause substantial deamidation in one...
The amide continues to react by the mechanism of acid-catalyzed amide hydrolysis we discussed above. Sign in to download full-size image In the base-catalyzed hydration of a nitrile, the first step of the process is a nucleophilic attack of hydroxide at the electrophilic carbon atom. Subsequent...
catalysis is growing rapidly a number of crucial factors remain to be investigated[151-164]. Kirbyet al.have researched the mechanism of the acid catalyzed hydrolysis of N-alkylmaleamic acids7-15to their correspondingmaleamic acidsand amines (Fig.10). The study found that the reaction is ...
The base-catalyzed, kOH-, pathway was mainly affected by the steric bulk of the nitrogen substituents in the amide moiety, the reactivity being reduced with larger N-substituents. Hydrolysis in human plasma appeared to be mediated by enzymic processes and is dependent upon the steric bulk in ...
Hydrolysis of Lipophilic Esters Catalyzed by a Zinc(II) Complex of a Long Alkyl-Pendant Macrocyclic Tetraamine in Micellar Solution A novel lipophilic zinc(II) complex with 1-hexadecyl-1,4,7,10-tetrazacyclododecane (hexadecylcyclen, L) has been synthesized, which is almost insoluble in ... Ei...
Acid-catalyzed hydrolysis should be avoided because of the likelihood of formation of anhydroretinol from retinol. If the sample does not contain sufficient amounts of natural antioxidants, it is recommended that an antioxidant be added before saponification. View chapterExplore book Introduction to ...
Internal (2+2) cycloaddition of the ester 7 gave the cyclobutene 8 in fair yield; cyclization of the readily derived trienone 4 and hydrolysis produced cor... ME Jung,KM Halweg - 《Tetrahedron Letters》 被引量: 192发表: 1981年 Total synthesis of d,l-coronafacic acid by an intermolecular...
High-Performance Liquid Chromatography analysis of GreenIuronic® (Figure 1) revealed the presence of HA, which was detected as the corresponding disaccharide ΔDi-HA generated by chondroitinase AC enzymatic hydrolysis of the Tremella extract. The identity of this disaccharide was established by compar...
The monosaccharides produced in cellulosic biomass hydrolysis can undergo dehydration to 5-hydroxymethylfuran under acid catalysis conditions. Then rehydration of this C6 furan in aqueous acidic medium can lead to the more stable C5 keto-acid, commonly known as levulinic acid (LA) with the loss of...
PreparationSuccinic acid can also be manufactured by catalytic hydrogenation of malic or fumaric acids. It has also been produced commercially by aqueous acid or alkalihydrolysis of succinonitrile derived from ethylene bromide and potassium cyanide (Gergel and Revelise, 1952; Gardner, 1972). ...