A process for the alkali hydrolysis of an amido ester to the corresponding amido acid is disclosed. The process is characterized by the steps of: A) hydrolyzing, in an aqueous alkaline media, an amido ester represented by formula (I), wherein R is selected from C1-20 alkyl, R1 is ...
The rate constant pertaining to the hydrolysis of the amide groups is independent of chain length and has the value of 0.24/hr.; this proves that in this system the principle of equal reactivity holds. [on SciFinder (R)] 关键词: mitochondria oxidative capacity DOI: 10.1002/pol....
The washing by protic solvents may evoke some hydrolysis of the polymer. Coupling agents such as phosgene and diphosgene in the presence of a base, tertiary amines or carbonate salt, can also be used for the polyanhydride formation (Domb et al., 1988). View chapter Chapter Pyrolysis of ...
Pharmacological blockade of the anandamide-degrading enzyme, fatty acid amide hydrolase (FAAH), produces CB1 receptor (CB1R)-mediated analgesic, anxiolytic-like and antidepressant-like effects in murids. Using behavioral and electrophysiological approaches, we have characterized the emotional phenotype and ...
Internal (2+2) cycloaddition of the ester 7 gave the cyclobutene 8 in fair yield; cyclization of the readily derived trienone 4 and hydrolysis produced cor... ME Jung,KM Halweg - 《Tetrahedron Letters》 被引量: 192发表: 1981年 Total synthesis of d,l-coronafacic acid by an intermolecular...
ishydrolysisof the anhydride. In aqueous solutions, anhydrides may break down by the addition of onemoleculeof water to yield two unreactive carboxylate groups. The presence of an excess of the anhydride in the reaction medium usually is used to minimize the effects of competing hydrolysis. ...
The effects of mepiquat chloride on the lateral root initiation of cotton seedlings are associated with auxin and auxin-conjugate homeostasis We prepared 19 amino acid conjugates of the plant hormone abscisic acid (ABA) and investigated their biological activity, enzymatic hydrolysis by a recombi... ...
Double bonds appeared to have an important impact on FAAH inhibitory activity. The macamides containing oleic, linoleic and linolenic acids produced FAAH inhibition of 64, 73, and 54%, respectively, while the macamide containing stearic acid and lacking a double bond produced only 13% inhibition ...
Intestinalphosphatasesand nucleosidases are capable of very efficienthydrolysisof coenzyme A so that near quantitative release ofpantothenic acidoccurs as a normal part of digestion. In rats, pantothenic acid was initially found to be absorbed in all sections of the small intestine by simple diffusion...
HDAC8 is a metal-dependent class I HDAC and is proposed to use a general acid-base catalytic pair in the mechanism of amide bond hydrolysis. Here, we report site-directed mutagenesis and enzymological measurements to elucidate the catalytic mechanism of HDAC8. Specifically, we focus on the ...