Brown, R. Studies in Amide Hydrolysis: The Acid, Base, and Water Reactions. The Amide Linkage: Selected Structural Aspects in Chemistry, Biochemistry and Materials Science; Wiley & Sons: New York, 2000.Brown, R. S. Studies in Amide Hydrolysis: the Acid, Base, and Water Reactions; John ...
Amide is a functional group in organic molecules that consists of an acyl group linked to a nitrogen atom. It provides structural rigidity and resistance to hydrolysis, and is found in proteins and drugs. It is formed through the reaction of a carboxylic acid with an amine or ammonia. ...
The characteristic reaction of covalent amides ishydrolysis(achemical reactionwith water), by which they are converted to acids and amines; this reaction ordinarily is slow unless it is catalyzed by a strong acid, analkali, or anenzyme. Amides also can be dehydrated to nitriles. Amides are not...
(HDLPs) indicates a conserved set of active site amino acid residues, suggesting that the hydrolysis reactions catalyzed by these enzymes likely share a common mechanism. The active site metal center in the eukaryotic HDAC8 is found at the bottom of a 12-Å deep narrow pocket wherein the ...
Under concentrated acid or base conditions, CAF-1 outperforms the current most stable imine COF in the literature24 (TPB-DMTP-COF, Fig. 5c and d), CAF-2 also affords the good stability expected for amides, outperforming TPB-DMTP-COF under acid conditions but not under basic conditions. CAF...
ratios of less than unity, the equilibrium hydrolysis experiments revealed that one base molecule could induce the hydrolysis of more than one amide group... L Gu,S Zhu,A.N. Hrymak - 《Journal of Applied Polymer Science》 被引量: 139发表: 2002年 Amino Acid Metabolism of Lemna minor L. ...
(as shown in Fig.1b). The conversion of amides to esters using alkyloxonium tetrafuoroborate salts has been previously reported in several studies27,28,29,30,31,32, involving the formation of imidate esters followed by subsequent hydrolysis to obtain amines and esters (as shown in Fig.1c)...
Fatty-acid amide hydrolase (FAAH) is an intracellular serine enzyme that catalyzes the hydrolysis of bioactive fatty-acid ethanolamides such as anandamide ... D Fegley,S Gaetani,A Duranti,... 被引量: 5发表: 2004年 The fatty-acid amide hydrolase inhibitor URB597 inhibits MICA/B shedding ...
Hydrolysis (a chemical reaction with water) is the reaction by which covalent amides are changed to acids and amines; this reaction is usually slow unless it is catalysed by a strong acid, an alkali, or an enzyme. Amides can also be dehydrated to produce nitriles. Amides are difficult to ...
With recalcitrant amides the use of nitrous acid can often be beneficial, the reaction proceeding via an intermediary diazonium ion. The formation of a diazonium ion significantly increases the rate of the hydrolysis reaction <1990TL3893>. The use of aqueous sodium peroxide <1975JOC1187> or ...