Rate for the hydrolysis of fluorescently labeled GTP analogs by the α0 and αi1 G-protein subunits Range of rate constants is limited to dissociation processes that are slow relative to the experimental time scale (t ≤ 1/koff) and the accuracy of koff values is based on the assumption ...
Valganciclovir, marketed as Valcyte, is an antiviral agent used for the treatment of cytomegalovirus. Called a prodrug, valganciclovir is inactive by itself but is rapidly converted in the intestine by hydrolysis of its ester bond to produce- How might...
Recently, our group demonstrated that the addition of MWCNT to rubber can considerably reduce the chlorine-induced degradation of the polymer matrix21. Although the degradation mechanism of rubber by chlorine is different from that of PA, particularly due to the lack of hydrolysis, covalent ...
4D). Like 1, compound 2 chelates zinc ion with its hydroxamic acid and makes a cation–π interaction with Arg824 via the triazole ring and a hydrogen bond with Ser138 via the carbonyl of the amide bond (Fig. 4E). The introduction of the second fluorine in compound 2 enhances IDE ...
presence of a boron-based reducing agent to stabilize the linkage between Cys188 and Lys296 by amination of the Schiff base, because the presence of a reactive protonated Schiff base can result in dissociation of the retinal-thio adduct or hydrolysis of the Schiff base (Supplementary Fig. 10b)...
presence of a boron-based reducing agent to stabilize the linkage between Cys188 and Lys296 by amination of the Schiff base, because the presence of a reactive protonated Schiff base can result in dissociation of the retinal-thio adduct or hydrolysis of the Schiff base (Supplementary Fig. 10b)...
Effect of food matrix and human gastrointestinal conditions on the in vitro protein hydrolysis of lentil proteins 2025, International Journal of Food Science and Technology Developments in the Dry Fractionation of Plant Components: A Review 2024, Separations Application of computational fluid dynamics simul...
Upon hydrolysis of the thioester bond, the released thiol group reacted rapidly with 5,5'-dithio-bis(2-nitrobenzoic acid) (DTNB) to produce a yellow color which was measured by a microtiter plate reader set at 405 nm. The rates of cleavage of the substrate by stromelysin in the presence ...
As a cationic poly(vinyl alcohol) having a cationic group as the modifying group, a compound is preferable which is produced in such a way that after a cationic monomer and a vinyl ester, such as vinyl acetate, are copolymerized with each other, hydrolysis (saponification) thereof is performe...
A method for encapsulating nucleic acids, particularly siRNAs, shRNAs, microRNAs, gene therapy plasmids, and other oligonucleotides in biodegradable polymers is disclosed, whereby the nucleic acids are formulated into reverse micelles composed of non-toxic and/or naturally-occurring lipids prior to nanopar...