7.6.3.1.2 Hydrolysis of amides Aminoacylases, amidases, and proteases are the most commonly used enzymes for amide bond cleavage, amidases (EC 3.5.1.4) being the enzymes most extensively used in this type of transformation. For instance cross linked enzyme crystals (CLEC) of the protease subt...
However, the impact of amide-to-ester substitutions on the membrane permeability of peptides has not been directly evaluated. Here we report the effect of amide-to-ester substitutions on the membrane permeability and conformational ensemble of cyclic peptides related to membrane permeation. Amide-to...
Vaisar, T., Urban, J.Gas-phase fragmentation of protonated mono-N-methylated peptides. Analogy with solution-phase acid-catalyzed hydrolysis.Journal of Mass Spectrometry.33, 505-524 (1998). Creighton, C. J., Romoff, T. T., Bu, J. H., Goodman, M.Mechanistic studies of an unusual ami...
(I) wherein Z is C═O and R3 is C1-4alkoxy, coupling a compound of Formula (II), or a protected or activated derivative thereof, and a compound of Formula (XII); or e) for compounds of Formula (I) wherein Z is absent and R3 is —CO2H, ester hydrolysis of compounds of Formula...
(I) wherein Z is C═O and R3 is C1-4alkoxy, coupling a compound of Formula (II), or a protected or activated derivative thereof, and a compound of Formula (XII); or e) for compounds of Formula (I) wherein Z is absent and R3 is —CO2H, ester hydrolysis of compounds of Formula...