Amide and peptide bond formation in water at room temperature. Org Lett. 2015;17(16): 3968-3971.Gabriel, C. M., Keener, M., Gallou, F. & Lipshutz, B. H. Amide and peptide bond formation in water at room temperature. Org. Lett. 17, 3968-3971 (2015)....
Peptide and amide bond-containing dendrimers. 来自 掌桥科研 喜欢 0 阅读量: 126 作者:L Crespo,G Sanclimens,M Pons,E Giralt,M Royo,F Albericio 摘要: Forsee ChemInformin Full Text.关键词: organic chemistry, review amino acids, peptides catenanes, cyclophanes, dendrimers, rotaxanes, calixarenes...
Peptide backbone modifications, involving either α-carbon changes or amide bond replacements, furnish new hybrid structures (pseudopeptides) with often profoundly altered physical and biological properties. Using both direct (ψ-condensation) and indirect (preformed pseudodipeptide) solid phase approaches,...
during the recent medchem exam there was one question in which a series of bioactive compounds were drawn, and among all, there were two compounds in which the only two differences were that: a) alkylic chain length was different and b) ester (-COO-) was replaced with the peptide (-CO...
For example, we used 62% TFA to cleave peptide 5 from resin and to remove the acid-labile protecting groups (Fig. 18). Surprisingly, we noted backbone amide cleavage next to the thioamide bond (thioamide substitution at i + 1 position of β-turn), which results from the nucleophilic ...
aL has no language in L没有语言[translate] aThe peptide Ac-LNLGG-OH was finally anchored by an amide bond, obtaining the “bidentate” compound 12 in 61% yield. 肽Ac LNLGGOH是氨化物债券nally停住的fi,获得“有二齿”化合物12在61%出产量。[translate]...
The method of the present invention is suitable for the commercial high-level production of a protein or peptide which can be used as a prophylactic and therapeutic drug for various diseases such as senile dementia, cerebrovascular dementia (dementia arising from cerebrovascular disorders), dementia as...
Dissociation of the amide bonds in a protonated peptide leads to N-terminal sequence fragments with cyclic structures and C-terminal sequence fragments with linear structures. The ionic fragments containing the N-terminus (b n ) have been shown to be protonated oxazolones, whereas those containing...
摘要: In this work, the cleavage activity of the metal complex [Cu(C21H21N3O2)(OH2)2]2+ is demonstrated to occur toward double-stranded DNA, in addition to its previously described amide bond cleavage activity, thus suggesting catalytic promiscuity for this complex. DOI: 10.1021/ic802208v ...
Original paper on the synthesis of peptide bonds/amide bonds using DCC.DeTar has published a series of papers studying the mechanism of the bond-forming reactions mediated by DCC and other carbodiimides, and here are the first two: Reactions of Carbodiimides. I. The Mechanisms of the Reactions...