Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunother- apy. FASEB J. 2017. Published online Nov 16. doi:10.1096/ fj.201700740RWang M, Yao LC, Cheng M, Cai D, Martinek J, Pan CX, Shi W, Ma AH, De Vere WR, Airhart S, et al. Humanized mice in ...
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We confirmed the engraftment of human PBMCs in both groups and the depletion of CD8+ T cells in pretransplant PBMCs and in hPBMCΔCD8T mice (Supplementary Fig. 1 and Fig. 1B). Fig. 1 hPBMC mice develop myositis symptoms in a CD8+ T cell-dependent manner. NSG mice were intravenously...
genO-hPD‑1/hPD‑L1 The genO‑hPD-1/hPD-L1 mouse model enablesin vivoefficacy assessment and profiling of molecules targeting the human PD-1/PD-L1 axis in fully immunocompetent mice. genO-hPD‑1/hTIM3 The genO‑hPD‑1/hTIM3 mouse enables thein vivoefficacy assessment and profilin...
Currently, we offer our unparalleled Magic™ human KI mice with a broad range of immune checkpoints, and the number is still increasing. We are also happy to construct custom transgenic mice/rats upon request. Immune Checkpoints CD47 PD-1 PD-L1 CTLA-4 TIM3 TIGIT BTLA LAG-3 OX40 GITR...
-fragment (Fc)-mediated anti-tumour activity (requiring Fcγ receptors for immunoglobulins, macrophages, dendritic cells and CD8+ T cells, as well as other components of the innate and adaptive immune systems) in multiple xenograft and syngeneic tumour models established in CD98-humanized mice. ...
The genO‑hCD39 mouse enables thein vivoefficacy assessment and profilingof immuno-oncology agents targeting the human immune checkpoint CD39 in fully immunocompetent mice. CT26-Pd-l1-ko The Pd-l1 Knockout colon carcinoma CT26 cell line is invalidated for murine Pd-l1 and can be used for ta...
A control group of mice received the same chow without RAL. Mouse blood was collected on day 1, 3, and 7 post-dosing to monitor the effects of RAL administration. In addition, spleens were collected at the end of week 4 post-ART from both viremic mice with vehicle dosing and aviremic...
Double-humanized genO‑hCD47/hSIRPα immunocompetent mice enable the efficacy assessment of anti-CD47/SIRPα. genO-hPD‑1/hGITR/hGITRL The genO-hPD-1/hGITR/hGITRL mouse model enablesin vivoefficacy assessment and profiling of antibodies targeting human immune checkpoint PD-1, GITR ...
6). The expression of most exhaustion markers on both allo CAR T cells and HIP CAR T cells recovered from the spleens were low, with the exemption of PD-1, which had been highly expressed even before the injection into mice (Supplementary Figs. 1d, 7, 8). We did not see differences...