*使用本品系发表的文献需注明: hPD-1/hPD-L1(BALB/c) mice (Cat. NO. NM-HU-220142) were purchased from Shanghai Model Organisms Center, Inc.. 相关品系 hVEGFA/hPD-1/hPD-L1 品系名:C57BL/6Smoc-Vegfatm1(hVEGFA)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Smoc ...
*Literature published using this strain should indicate: hPD-1 mice (Cat. NO. NM-HU-00015) were purchased from Shanghai Model Organisms Center, Inc.. Validation Data Data from flow cytometry (FACS) analysis Fig1 . Expression of PD-1 in the activated spleen lymphocytes of humanized PD-1 Hom...
*使用本品系发表的文献需注明: hPD-1 mice (Cat. NO. NM-HU-00015) were purchased from Shanghai Model Organisms Center, Inc.. 验证数据 RT-PCR验证数据 Fig1. Detection of PD-1 expression by RT-PCR. Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type. ...
hSIRPA/hCD47(BALB/c)(NM-HU-210020) mice was crossed with hPD-1/ hPD-L1(BALB/c)(NM-HU-220142) mice to generate hPD-1/hPD-L1/hCD47/hSIRPA(BALB/c) mice. *Literature published using this strain should indicate: hPD-1/hPD-L1/hCD47/hSIRPA(BALB/c) mice (Cat. NO. NM-HU-220143...
*使用本品系发表的文献需注明: hPD-1/hPD-L1 mice (Cat. NO. NM-HU-00100) were purchased from Shanghai Model Organisms Center, Inc..验证数据图1 FACS 检测 PD-1&PD-L1 双人源化纯合子小鼠人源 PD-1 和 PD-L1 的表达。结果显示在 PD-1&PD-L1 双人源化纯合子小鼠可以检测到人源 PD-1 和...
Protein expression analysis Strain specific PD1 and PD-L1 expression analysis in homozygous B-hPD-1/hPD-L1 mice by flow cytometry. Splenocytes were collected from WT and homozygous B-hPD-1/hPD-L1 (H/H) mice stimulated with anti-CD3ε
b-hpd-1/hox40 mice 基本信息 基因简介 pd-1(programmed death-1) 主要表达于t细胞及初级b细胞表面,广泛表达于抗原提呈细胞(apcs)等。pd-1与其受体的相互作用,在免疫应答的负性调控方面发挥着重要作用。肿瘤部位的微环境可诱导肿瘤细胞上的pd-l1的表达,表达的pd-l1有利于肿瘤发生和生长,诱导抗肿瘤t细胞的凋亡...
homozygous B-hPD-1/hPD-L1/hTIGIT (H/H) mice analyzed by flow cytometry with species-specific anti-PD-1 antibody. Mouse PD-1, PD-L1 and TIGIT were detectable in WT mice. Human PD-1, PD-L1 and TIGIT were exclusively detectable in homozygous B-hPD-1/hPD-L1/hTIGIT but not WT mice....
Human PD-1 transgenic mice were used to analyze the in vivo anti-tumor effects of the ADC and its combination therapy with PD-1/PD-L1 antibody. Results: The combination of RC48 and PD-1/PD-L1 immune checkpoint inhibition significantly enhanced tumor suppression and antitumor immunity. Tumor ...
A novel HER2-targeting ADC combined with immune checkpoint inhibitors can achieve remarkable effects in mice and elicit long-lasting immune protection in a hHER2+murine breast cancer model. This study provides insights into the efficacy of RC48 therapeutic activity and a rationale for potential ...