PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc Natl Acad Sci U S A 2004;101:10691-6.PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells...
Furthermore, Tregs abundance was also increased in both the spleen and circulation of Pmel-1 mice treated with PD-L1. These data indicate that PD-L1 protein therapy inhibits the immune response and reverses depigmentation development in Pmel-1 vitiligo mice....
The pharmacokinetic parameters of PD-1/PD-L1-IN-29(S4-1) in mice Parameters iv (5 mg/kg) po (50 mg/kg) T1/2 (h) 9.78 4.77 Tmax (h) 0.08 0.92 Cmax (ng/mL) 6290 260.67 AUC0-t (h*ng/mL) 3466.58/td> 808.04 AUC0-∞ (h*ng/mL) 3566.62 830.34 CL (mL/h/kg) 1404.22 - ...
Nishimura H,Okazaki T,Tanaka Y,et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice[J]. Science,2001,291( 5502) : 319-322. [18] Okazaki T,Tanaka Y,Nishio R,et al. Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice...
[2]An mRNA therapy improves breast cancer response to immunotherapy in mice(来源:FierceBiotech) [3]Radical increase in the effectiveness of breast cancer immunotherapy(来源:Hospital del MarMedical Research Institute)
Conclusion:Anti-PD-L1 antibody therapy can inhibit the growth of CMT167 mouse lung cancer cell xenografts in mice, which may be related to the decrease of MDSCs in spleen and increase of CD8+ T cell infiltration in...
2.Hams E, Locksley RM, McKenzie AN, Fallon PG. Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J Immunol. 2013;191(11):5349-5353. doi:10.4049/jimmunol.1301176 3.Molofsky AB, Nussbaum JC, Liang HE, et al. Innate lymphoid ...
2.Hams E, Locksley RM, McKenzie AN, Fallon PG. Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J Immunol. 2013;191(11):5349-5353. doi:10.4049/jimmunol.1301176 3.Molofsky AB, Nussbaum JC, Liang HE, et al. Innate lymphoid ty...
(Fig.1c). Deficiency in PD-L1 does not affect DC development, as similar numbers of cells were found in the spleen and lymph node (LN) of conditional knockout mice (Supplementary Fig.1b–f). To test the physical contribution of PD-L1 on DC, wild-type (WT) MC38 cells were ...
Figure 5. Treatment efficacy of PD-1 blockade immunotherapy was compromised in DDP-treated mice 6.SHR-1701克服淋巴细胞恢复力受损小鼠对PD-1单抗的获得性耐药 将肺癌原位小鼠模型分为6个处理组:对照,DDP,PD-1抑制剂,DDP+PD-...