为了明确PD-1-PD-L1对于Treg的影响,首先给与Naive mice anti-PDL1抗体发现能够显著促进Treg的比例,并且增加的主要为PD1+ Treg(b),也显著增加了IL-10的表达了,并且验证发现IL-10导致的cDC2以及巨噬细胞比例显著降低。这与前期报道的PD-1KO小鼠...
1. PD-1 is upregulated during chronic viral infection acute/chronic infections in adult mice: LCMV different strain microarray analysis of genes expressed by LCMV-specific CD8 T cells Kinetics of PD-1 expression on CD8 T cells 2. PD-L1 blockade enhances viral control and T-cell responses LCMV...
此外,CD8+或CD4+和CD8+T细胞耗尽的Ag on/CPI小鼠的病理评分与Ag小鼠的病理评分没有统计学差异(中位数=2.5)。 为了明确Ag on/CPI小鼠皮肤病的CD8 T细胞依赖机制,作者使用过继转移的N/C小鼠,从TCR转基因的P14 MICE26(称为P14 CD8 T细胞)中过继地转移了天然标记的THY1.1+dsRED表达的或萤火虫荧光素酶(Fluc)表达...
*使用本品系发表的文献需注明: Pd-1-KO mice (Cat. NO. NM-KO-190423) were purchased from Shanghai Model Organisms Center, Inc.. 疾病预测 膀胱炎 Cystitis 近似模型的表型 MGI:5574062 注:该品系需与Fcgr2b-KO(3)(NM-KO-210279)交配才可能获得预期表型 ...
*使用本品系发表的文献需注明: Pd-1-KO mice (Cat. NO. NM-KO-190423) were purchased from Shanghai Model Organisms Center, Inc.. 疾病预测 膀胱炎 Cystitis 近似模型的表型 MGI:5574062 注:该品系需与Fcgr2b-KO(3)(NM-KO-210279)交配才可能获得预期表型 ...
Further, Smad3 is a crucial transcription factor responsible for TGF-β-induced PF, as Smad3 KO mice were protected from bleomycin induced PF42. PD-L1 has also been reported to express in the nuclei of certain cancer types21,43. We found that TGF-β treatment increased levels of PD-L1 ...
我们在过继共转移环境中进行了研究,其中野生型 (WT) 和PD-1敲除 (KO) 的抗原特异性T细胞的所有环境因素都是相同的,从而绕过了混杂变量如克隆竞争、病毒载量改变或通过抑制PD-1信号传导对其他免疫细胞的间接影响。这些研究将对免疫接种产生影响,其中人们可以通过控制PD-1的表达来促进记忆CD8 T细胞的形成,甚至在...
Fate of naïve WT and PD-1 KO CD4+ cells transferred into WT and PD-1 KO mice.Joanna J. CharltonDebbie TsoukatouClio MamalakiIoannis Chatzidakis
l1结合,从而激活免疫系统以攻击肿瘤。因此,pd ‑ 1抑制剂在治疗一些类型的癌症方面取得了不同程度的成功。 8.还发现抑制pd ‑ 1活性在动物中减少脑淀粉样蛋白β斑块并改善认知能力。阻断pd ‑ 1活性被证明会引发ifn ‑ γ依赖性免疫应答,该应答将单核细胞衍生的巨噬细胞募集到大脑,其然后能够从组织中清除...
敲除Pdcd1lg2基因exon 3-5,建立Pdcd1lg2基因敲除小鼠模型。 应用领域:免疫相关,自我耐受、th1和th2免疫反应相关。 *使用本品系发表的文献需注明: Pdcd1lg2-KO mice (Cat. NO. NM-KO-190728) were purchased from Shanghai Model Organisms Center, Inc.. ...