2025年1月21日， 复旦大学药学院陆伟教授和上海交通大学医学院肖泽宇教授团队在期刊《Nature Communications》上发表了题为“CD133PD-L1 cancer cells confer resistance to adoptively transferred engineered macrophage-based therapy in melanoma++”的研
6.Nishimura S, Manabe I, Nagasaki M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15(8):914-920. doi:10.1038/nm.1964 7.Yang H, Youm YH, Vandanmagsar B, et al. Obesity increases the production of proinfla...
In this study, we investigated whether PD-1 and PD-L1 interaction between macrophages and T cells alters macrophage activities. Our data provide evidence for PD-1/PD-L1 engagement inducing a regulatory profile in macrophages. Regulatory macrophages derived from PD-L1 signaling lost their host ...
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15(8):914-920. doi:10.1038/nm.1964 7.Yang H, Youm YH, Vandanmagsar B, et al. Obesity increases the production of proinflammatory mediators from adipose tissue T cells and ...
6.Nishimura S, Manabe I, Nagasaki M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15(8):914-920. doi:10.1038/nm.1964 8.Kanneganti TD, Dixit VD. Immunological complications of obesity. Nat Immunol. 2012;13(8...
macrophage [ˈmækrəfeɪdʒ] 巨噬细胞 lymphocyte [ˈlɪmfəsaɪt] 淋巴细胞 B cells - bone marrow - humoral response T cells (两大类helper and cytotoxic [,saitə'tɔksik] 细胞毒素的) - thymus [ˈθaɪməs] 胸腺 - cell-mediated ...
OVs的抗肿瘤疗效 截至2021年10月1日,目前已完成的OVs临床研究共132项。根据研究结果,我们发现OVs,如H101、T-VEC、G47Δ、一氧化二氢、T3011和G47Δ具有显著的抗肿瘤作用(表2)。MPE, malignant pleural effusion; HSV-1, herpes simplex virus type 1; GM-CSF, granulocyte-macrophage colony-stimulating factor...
ICD(Immunogenic Cell Death),免疫原性细胞死亡;M1(M1-like macrophage),M1样巨噬细胞;M2(M2-like macrophage),M2样巨噬细胞;MDSC(Myeloid-derived Suppressor Cell),骨髓源性抑制细胞;DC(Dendritic Cell),树突状细胞;CTL(Cytotoxic T ...
CD47与CD47抗体 CD47是一个天然的免疫抑制蛋白分子，广泛表达于正常细胞表面，通过与巨噬细胞(Macrophage)表面的SIRPα结合，释放一种“别吃我”信号，从而保护健康细胞不被巨噬细胞吞噬。不幸的是，大部分癌细胞的表面也都有高水平的CD47表达，使巨噬细胞将它们当作“正常细胞”，从而躲避了被“吃掉”的命运。经过...
Interestingly, intracellular levels of IL-10, IL-6, TNF-伪, and IFN-纬 in PD-L1+CD68+ macrophage were higher than those in PD-L1鈭扖D68+ macrophage, especially IL-6 expression. Based on the PD-L1 receptor PD-1 expression on tumor-infiltrating cytotoxic cells, our data supported that ...