6.Nishimura S, Manabe I, Nagasaki M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15(8):914-920. doi:10.1038/nm.1964 7.Yang H, Youm YH, Vandanmagsar B, et al. Obesity increases the production of ...
2025年1月21日， 复旦大学药学院陆伟教授和上海交通大学医学院肖泽宇教授团队在期刊《Nature Communications》上发表了题为“CD133PD-L1 cancer cells confer resistance to adoptively transferred engineered macrophage-based therapy in melanoma++”的研究论文。研究结果表明，与CD133PD-L1癌细胞相比，CD133PD-L1癌细...
In this study, we investigated whether PD-1 and PD-L1 interaction between macrophages and T cells alters macrophage activities. Our data provide evidence for PD-1/PD-L1 engagement inducing a regulatory profile in macrophages. Regulatory macrophages derived from PD-L1 signaling lost their host ...
P., Yang, Y., Nickles, D., and Cubas, R. (2019). Anti–PD-L1 treatment results in functional remodeling of the macrophage compartment. Cancer Res. 79, 1493–1506. https://doi.org/10.1158/0008-5472.CAN-18-3208.想
ICD(Immunogenic Cell Death),免疫原性细胞死亡;M1(M1-like macrophage),M1样巨噬细胞;M2(M2-like macrophage),M2样巨噬细胞;MDSC(Myeloid-derived Suppressor Cell),骨髓源性抑制细胞;DC(Dendritic Cell),树突状细胞;CTL(Cytotoxic T ...
正常生理状况下，PD-1/PD-L1抑制性共刺激信号的主要作用是防止T细胞不受控制地过度活化攻击正常细胞。不同类型肿瘤细胞表面表达高水平的PD-L1，这些过度表达的PD-L1通过PD-1/PD-L1信号途径诱导T细胞衰竭，使肿瘤细胞逃避T细胞免疫攻击，直接影响肿瘤患者的治疗效果及临床预后。PD-1/PD-L1通路阻断剂，包括PD-1单...
6.Nishimura S, Manabe I, Nagasaki M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15(8):914-920. doi:10.1038/nm.1964 7.Yang H, Youm YH, Vandanmagsar B, et al. Obesity increases the production of proinflamm...
当骨髓瘤细胞特异性抗原被淋巴细胞识别并攻击时,一方面活化T细胞使其表达PD-1并产生γ链细胞因子,与白介素-21及干扰素-γ共同诱导骨髓瘤细胞及免疫细胞表达PD-L1,另一方面活化B细胞与树突细胞使其分泌粒细胞-巨噬细胞集落刺激因子(...
macrophage [ˈmækrəfeɪdʒ] 巨噬细胞 lymphocyte [ˈlɪmfəsaɪt] 淋巴细胞 B cells - bone marrow - humoral response T cells (两大类helper and cytotoxic [,saitə'tɔksik] 细胞毒素的) - thymus [ˈθaɪməs] 胸腺 - cell-mediated ...
6MW3211是共轻链结构，采用差异化的亲和力设计，以确保优先结合到表达PD-L1的肿瘤细胞，并在此基础上发挥CD47抗体臂的阻断作用，同时活化T细胞及Macrophage的抗肿瘤作用。临床前研究显示，6MW3211完全不结合人及恒河猴的红细胞。进一步的晶体结构数据显示，CD47上的两个N-糖基化位点参与了跟6MW3211的结合，提示了6MW...