2025年1月21日， 复旦大学药学院陆伟教授和上海交通大学医学院肖泽宇教授团队在期刊《Nature Communications》上发表了题为“CD133PD-L1 cancer cells confer resistance to adoptively transferred engineered macrophage-based therapy in melanoma++”的研究论文。研究结果表明，与CD133PD-L1癌细胞相比，CD133PD-L1癌细...
6.Nishimura S, Manabe I, Nagasaki M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15(8):914-920. doi:10.1038/nm.1964 7.Yang H, Youm YH, Vandanmagsar B, et al. Obesity increases the production of ...
P., Yang, Y., Nickles, D., and Cubas, R. (2019). Anti–PD-L1 treatment results in functional remodeling of the macrophage compartment. Cancer Res. 79, 1493–1506. https://doi.org/10.1158/0008-5472.CAN-18-3208.想
In this study, we investigated whether PD-1 and PD-L1 interaction between macrophages and T cells alters macrophage activities. Our data provide evidence for PD-1/PD-L1 engagement inducing a regulatory profile in macrophages. Regulatory macrophages derived from PD-L1 signaling lost their host ...
6.Nishimura S, Manabe I, Nagasaki M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15(8):914-920. doi:10.1038/nm.1964 8.Kanneganti TD, Dixit VD. Immunological complications of obesity. Nat Immunol. 2012;13(8...
macrophage [ˈmækrəfeɪdʒ] 巨噬细胞 lymphocyte [ˈlɪmfəsaɪt] 淋巴细胞 B cells - bone marrow - humoral response T cells (两大类helper and cytotoxic [,saitə'tɔksik] 细胞毒素的) - thymus [ˈθaɪməs] 胸腺 - cell-mediated ...
ShimuraK, et al.The role of myeloid-derived suppressor cells in increasing cancer stem-like cells and promoting PD-L1 expression in epithelial ovarian cancer[J]．Cancer Immunol Immunother, 2020, 69(12): 2477-2499.DOI: 10.1007/s00262-020-02628-2.LiuC, YaoZ, WangJ, et al.Macrophage-derive...
17. Klug F, Prakash H, Huber PE, Seibel T, Bender N, Halama N,et al. Low-dose irradiation programs macrophage differentiation to an iNOS(þ)/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell 2013;24:589-602. ...
LiuC, YaoZ, WangJ, et al.Macrophage-derived CCL5 facilitates immune escape of colorectal cancer cells via the p65/STAT3-CSN5-PD-L1 pathway[J].Cell Death Differ, 2020, 27(6): 1765-1781.DOI:10.1038/s41418-019-0460-0. ZhangP, SuDM, L...
6.Nishimura S, Manabe I, Nagasaki M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15(8):914-920. doi:10.1038/nm.1964 7.Yang H, Youm YH, Vandanmagsar B, et al. Obesity increases the production of proinflamm...