glycolysis, which was essential for PD-1 inhibition to augment TAM expression of CD86 and major histocompatibility complex I and II molecules and ability to activate T cells. Myeloid-specific PD-1 deficiency slowed tumour growth, enhanced TAM glycolysis and antigen-presentation capability, and led to...
Endoplasmic reticulum stressed HNSCC cell-derived exosomal miR-26a-5p promotes PD-L1 expression in macrophage through PTEN/AKT signaling pathwaydoi:10.12016/j.issn.2096-1456.2024.01.003endoplasmic reticulum stressmacrophageexosomehead and neck squamous cell carcinomamiR-26a-5p...
正常生理状况下，PD-1/PD-L1抑制性共刺激信号的主要作用是防止T细胞不受控制地过度活化攻击正常细胞。不同类型肿瘤细胞表面表达高水平的PD-L1，这些过度表达的PD-L1通过PD-1/PD-L1信号途径诱导T细胞衰竭，使肿瘤细胞逃避T细胞免疫攻击，直接影响肿瘤患者的治疗效果及临床预后。PD-1/PD-L1通路阻断剂，包括PD-1单...
13. Shirasawa M, Yoshida T, Imabayashi T, et al. Baseline PD-L1 expression and tumour-infiltrated lymphocyte status predict the efficacy of durvalumab consolidation therapy after chemoradiotherapy in unresectable locally advanced...
SatoH, NiimiA, YasuharaT, et al.DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells[J].Nat Commun, 2017, 8(1): 1751.DOI:10.1038/s41467-017-01883-9. CoelhoMA, de Carné TrécessonS, RanaS, et al.Oncogeni...
macrophage.33Histone lactylation also participates in immune regulation. During M1 macrophage polarization, increased H3K18 lactylation significantly induces the expression of homeostatic genes involved in wound healing, such as Arg1.30Besides, the transition of macrophage from inflammatory to reparatory ...
Programmed death receptor-ligand 1 (PD-L1) plays a crucial role in immune evasion by tumour cells. Most tumour cells exhibit energy dependency and acquire energy from glycolysis. However, the relationship between glucose metabolism and PD-L1 expression remains unclear. In this study, changes in P...
事实上,MYC失活会导致肿瘤细胞PDL1与CD47表达降低(PDL1表达高,会告诉T细胞don’t eat me;同时CD47表达高,会告诉macrophage以及树突细胞don’t eat me),从而促使免疫细胞对肿瘤细胞进行攻击。在MYC失活的条件下,转染PDL1或CD47,会阻止肿瘤组织内T细胞浸润的累积,从而逆转MYC失活导致的免疫攻击(Casey et al., 2016...
Treatment of mouse and human macrophages with PD-L1 antibodies increased spontaneous macrophage proliferation, survival, and activation (costimulatory molecule expression, cytokine production). Similar changes were observed in macrophages incubated with soluble CD80 and soluble PD-1, and in PD-L1-/- ...
当骨髓瘤细胞特异性抗原被淋巴细胞识别并攻击时,一方面活化T细胞使其表达PD-1并产生γ链细胞因子,与白介素-21及干扰素-γ共同诱导骨髓瘤细胞及免疫细胞表达PD-L1,另一方面活化B细胞与树突细胞使其分泌粒细胞-巨噬细胞集落刺激因子(...