(2013). Macrophage PD- L1 strikes back: PD-1/PD-L1 interaction drives macrophages toward regulatory subsets. Adv. Biosci. Biotechnol. 4, 19-29. doi:10.4236/abb.2013.48A3003Lee Y., Moon Y., Hyung K., Yoo J., Lee M., Lee I., et al. (2013). Macrophage PD-L1 strikes back: PD...
The role of the PD-1/PD-L pathway, which is fundamental in T cell biology16, is controversial in the context ofM.tuberculosisinfection. Considering other diseases, it was shown that the PD-1/PDL pathway is an important checkpoint in cancer immunotherapy, since the inhibition of this pathway ...
Programmed death (PD)-1 attenuates macrophage activation and brain inflammation via regulation of fibrinogen-like protein 2 (Fgl-2) after intracerebral hemorrhage in miceProgrammed death (PD)-1 attenuates macrophage activation and brain inflammation via regulation of fibrinogen-like protein 2 (Fgl-2) ...
Programmed cell death 1(PD-1)/PD-1 ligand (PD-L1) checkpoint blockade is a promising clinical anticancer treatment modality by blocking the binding of PD-L1 on tumor cells to PD-1 on activated T cells to reactivate T-cell-mediated antitumor immunity1,2,3. However, the durable response rat...
Tumor-associated macrophages (TAMs) express PD-L1 and contribute to the immune-suppressive tumor microenvironment. Although the role of the PD-L1 and PD-1 interaction to regulate T-cell suppression is established, less is known about PD-L1 signaling in macrophages and how these signals may affect...
do not show good response to the PD-1/PD-L1 targeted monotherapy. Till now, the widely accepted anti-tumor mechanism of PD-1/PD-L1 blockade is rejuvenating T cells, there is lack of studies which focus on other components of the tumor environment in the treatment of cancer with PD-1/...
Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression doi:10.1158/2767-9764.CRC-23-0513High-grade serous carcinoma (HGSC) of the fallopian tube, ovary, and peritoneum is the most common type of ovarian cancer and is predicted to be immunogenic ...
Interestingly, programmed death ligand 1 (PD-L1), a critical regulator of M2 polarization, was downregulated in SPP1 knockdown THP-1 cells. Inhibition of PD-L1 induced a greater decline of the M2 markers IL-10 and Arg-1 but an increase in the M1 markers IL-12 and TNF-α. In addition...
Background Immune checkpoint blockade targeting the PD-1/PD-L1 axis has revolutionized the treatment of many solid tumors. PD-L1 expression is known to be modulated by both infiltrating T cells and by tumor intrinsic mechanisms. Therapeutics targeting the macrophage checkpoints CD47 and SIRP伪 are...
PD-1/L1 inhibitor indirectly induces myocardial injury by mediating macrophage transformation.M1 macrophages provoke cardiomyocyte inflammation, leading to pyroptosis.hBMSC-Exos exert cardioprotective effects by inhibiting cardiomyocyte pyroptosis.hBMSC-Exos combined with PD-1/L1 inhibitor alleviate heart damage ...