Johnson CH, Bonzo JA, Cheng J et al (2013) Cytochrome P450 regulation by alpha-tocopherol in Pxr-null and PXR-humanized mice. Drug Metab Disp 2:406–413JOHNSON, C H et al, Cytochrome P450 Regulation by α-Tocopherol in Pxr-Null and PXR-Humanized Mice, Drug Metabolism and Disposition, v...
Quantitative analysis for induction of CYP3A in a new double humanized mice of PXR/SXR (knock-in) and CYP3A (transchromosomic)Jiro Kuze
Mota, L.C.; Barfield, C.; Hernandez, J.P.; Baldwin, W.S. Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment. Toxicol. Appl. Pharmacol. 2011, 252, 259-267....
Results RIF decreased the hepatic protein levels of superoxide dismutase-1, thioredoxin-1, and 纬-glutamylcysteine ligase catalytic subunit in wild-type (WT) mice, but not in the double humanized mice. Catalase protein levels were decreased by RIF in both WT and double humanized mice. The ...
The present study investigated the hepatic regulation of cytochrome P450s (CYPs) and UDP-glucuronosyltransferases (UGTs) in the pregnane X receptor (PXR) and the constitutive androstane receptor double humanized mice treated with rifampicin (RIF; 10mg/kg) for 4 days. RIF increased hepatic ...
Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR. Toxicol Sci 2014;140:259-70.Braeuning, A., et al. (2014), 'Phenobarbital-Mediated Tumor Promotion in Transgenic Mice with Humanized CAR and PXR', Toxicol Sci....
Braeuning A, Gavrilov A, Brown S, Wolf CR, Henderson CJ, Schwarz M (2014) Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR. Toxicol Sci 140:259–270Braeuning, A., Gavrilov, A., Brown, S., Wolf, C. R., Henderson, C. J., and Schwarz, M. (...
humanized mice treated with the human PXR ligand, rifampicin (RIF; 10 mg/kg for 4 days).ResultsRIF decreased the hepatic protein levels of superoxide dismutase-1, thioredoxin-1, and 纬-glutamylcysteine ligase catalytic subunit in wild-type (WT) mice, but not in the double humanized mice. Cat...
Braeuning A, Gavrilov A, Brown S, Wolf CR, Henderson CJ, Schwarz M (2014) Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR. Toxicol Sci 140:259–270Braeuning, A., Gavrilov, A., Brown, S., Wolf, C. R., Henderson, C. J., and Schwarz, M. (...