Johnson CH, Bonzo JA, Cheng J et al (2013) Cytochrome P450 regulation by alpha-tocopherol in Pxr-null and PXR-humanized mice. Drug Metab Disp 2:406–413JOHNSON, C H et al, Cytochrome P450 Regulation by α-Tocopherol in Pxr-Null and PXR-Humanized Mice, Drug Metabolism and Disposition, v...
As a biomarker for leukocyte infiltration into inflamed tissue, MPO activity was determined. The results showed that the MPO activity in the colon tissue was markedly increased in mice receiving DSS alone treatment compared with control mice (Table1). However, MPO activity in DSS model group was ...
Dr. Xie’s research is conducted using a combination of cell cultures and genetically engineered mice that include transgenic, knockout and humanized mice. Dr. Xie has authored more than 230 journal articles and book chapters. Dr. Xie’s papers have been cited for nearly 14,000 times, and ...
Mice resulting from this breeding step that were positive for the human PXR transgene by PCR analysis were bred further with PXR-null mice. Mice positive for the human PXR transgene and the PXR null allele, as determined by PCR genotyping, were designated as PXR-humanized transgenic (hPXR) ...
Quantitative analysis for induction of CYP3A in a new double humanized mice of PXR/SXR (knock-in) and CYP3A (transchromosomic)Jiro Kuze
which is consistent with our result. Another potential pathogenesis of ATDH is the imbalance between production of reactive oxygen species and detoxification of reactive intermediates39. Gonget al. found that mice treated with aPXRagonist and cell lines with activated humanPXRshowed heightened sensitivit...
PXR/CYP3A4-Humanized Mice for Studying Drug–Drug Interactions Involving Intestinal P-Glycoprotein Rodent models are less suitable for predicting drug鈥揹rug interactions at the level of the human intestinal mucosa, especially when nuclear receptors such... N Holmstock,FJ Gonzalez,M Baes,... - 《...
Results The pharmacokinetic parameters including AUC and T1/2were significantly different among the PXR genotype groups. The SNPs of −298G/G and 11193C/C were found to be associated with a lower PXR activity resulting in reduction of CYP3A4 activity in vivo. After administration of flucloxacil...
Mota, L.C.; Barfield, C.; Hernandez, J.P.; Baldwin, W.S. Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment. Toxicol. Appl. Pharmacol. 2011, 252, 259-267....
Results RIF decreased the hepatic protein levels of superoxide dismutase-1, thioredoxin-1, and 纬-glutamylcysteine ligase catalytic subunit in wild-type (WT) mice, but not in the double humanized mice. Catalase protein levels were decreased by RIF in both WT and double humanized mice. The ...