Also there was a difference in stability between the depurinating and non-depurinatingstem-loops, which probably is due to the 2011b. Self-catalyzed site-specific depurination of Gresidues mediated by cruciform extrusion in closed circular DNA plasmids. J Bio Chem.S KodaliKodalisreeja Com...
Baserga;SJ;Benz;EJ;Jr.Nonsense mutations in the human beta-globin gene affect mRNA metabolism.0.2056-2060Baserga SJ, Benz EJ Jr (1988) Nonsense ... S,J,Baserga,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 356发表: 1988年 Splicing...
(1991) Human γ-globin genes silenced independently of other genes in the β-globin locus. Nature, 350, 252-254.Dillon N,Grosveld F.Human γ-globin genes silenced independently of other genes in the βglobin gene locus. Nature . 1991...
IVSII-666 of human beta-globin gene: a polymorphic marker linked to codon 8(-AA) mutation. 来自 NCBI 喜欢 0 阅读量: 49 作者: Akhavan-Niaki, Haleh, Seresti, Siamak Shafiezadeh, Asghari, Beheshteh, Banihashemi, Ali 摘要: AIMS: IVSII-666 (C-T) is one of the polymorphic sites ...
Structure of the human G gamma-A gamma-delta-beta-globin gene locus. Proc Natl Acad Sci U S A. 1979 Oct; 76 (10):4827–4831.Bernards R, Little PF, Annison G, Williamson R, Flavell RA. Structure of the human G gamma-A gamma-delta-beta-globin gene locus. Proc Natl Acad Sci U ...
The β-haemoglobinopathies, such as sickle cell disease and β-thalassaemia, are caused by mutations in the β-globin (HBB) gene and affect millions of people worldwide. Ex vivo gene correction in patient-derived haematopoietic stem cells followed by aut
The β and δ chains of hemoglobins A and Aare very similar in structure and are encoded by genes that are tightly linked, yet in the red cell β chain production is 40 fold greater than production of the δ chain, providing an excellent model for studying the control of gene expression...
24,25 These vectors failed to express therapeutic levels of globin and in some instances exhibited significant silencing over time.26,27 The goal of our studies was to derive a vector capable of high-level expression of the human γ-globin gene. Patients with either β-thalassemia or sickle ...
We have studied the expression of a cloned mutant human β -globin gene in tissue culture cells. The gene, which was previously isolated from the chromosomal DNA of an individual with a low level of normal β -globin expression (β+-thalassemia), contains five mutations inside the large inter...
Beta ThalassemiaGene TargetingHomologous RecombinationGene TherapyObjective: Replacment of CD133+ cell's 尾 globin gene by using a gene targeting constructcontaining the 尾 globin gene and essential elements for homologous recombination.Materials and Methods: pFBGGT was amplified, then digested using the ...