We report here a detailed analysis of globin gene switching in these early human erythroblasts as a function of time of co-culture of the hESCs on the FH-B-hTERT cells.Caihong QiuEmmanuel OlivierEric E. BouhassiraBlood cells, molecules and diseases...
giobin gene dupiication and identify the reguiatory eiements present in the giobin genes,we cioned the !- and "- giobin genes of P. crocea and investigated the two giobin genes arrangement. Linkage anaiysis reveaied that the !- and "- giobin genes were orien- ted head-to-head rei...
The beta-globin gene cluster is located on chromosome 11. SNPs database was published by Hap Map Project. Here, novel tag SNPs on beta -globin gene cluster in Chinese Han population was reported on using Haploview 4.2. The haplotype block and LD analysis showed three blocks that were ...
doi:10.4274/jpr.37450GENETIC polymorphism researchHEMOGLOBINSA letter to the editor is presented which discusses a polymorphism of a novel beta globin gene in Turkish population.Journal of Pediatric ResearchAkar, NejatCeylaner, SerdarDoan, Haldun...
We have studied the transient expression of a cloned rabbit hemoglobin β1 gene after its introduction into HeLa cells. Two and one-half days after transfection using the calcium phosphate technique, we extracted RNA from the entire cell population and analyzed it by the S1 nuclease hybridization ...
The beta-thalassemia is associated with abnormality in beta-globin gene, leading to imbalanced synthesis of alpha-/beta-globin chains. Consequently, the excessive free alpha-globin chains precipitate to the erythrocyte membrane, resulting in hemolytic anemia. We have explored post-transcriptional strategie...
Evidences indicate that locus control region (LCR) of beta-globin spatially closes to the downstream active gene promoter to mediate the transcriptional activation by looping. DNA binding proteins may play an important role in the looping formation. NF-E2 is one of the key transcription factors in...
In vitro studies using the cloned β -39 gene have reproduced this effect in a heterologous transfection system and have suggested that the defect resides in intranuclear metabolism. We have asked if this phenomenon of decreased mRNA accumulation is a general property of nonsense mutations and if ...
To assess the relationship between being beta globin gene carrier and developing insulin resistance.This study was conducted on 164 subjects including 82 healthy ones and 82 patients with beta thalassemia minor (microcytosis (MCV <80 fl) and hypochromia (MCH <25 pg) and HbA2 ≥ 3.5% using HP...
Sardinian delta beta 0-thalassemia is an inherited syndrome characterized by the inactivity of the beta-globin gene and the persistent activity of the fetal gamma-globin genes, particularly the A gamma-globin gene. Previous mapping studi... S Guida,B Giglioni,P Comi,... - 《Embo Journal》 ...