( 1993 ) Synthetic human β-globin 5′HS2 constructs function as locus control regions only in multicopy transgene concatamers . EMBO J. 12 , 127 – 134 .Ellis J, D Talbot, N Dillon & F Grosveld: Synthetic human beta-globin 5'HS2 constructs function as locus control regions only in ...
IVSII-666 of human beta-globin gene: a polymorphic marker linked to codon 8(-AA) mutation. 来自 NCBI 喜欢 0 阅读量: 49 作者: Akhavan-Niaki, Haleh, Seresti, Siamak Shafiezadeh, Asghari, Beheshteh, Banihashemi, Ali 摘要: AIMS: IVSII-666 (C-T) is one of the polymorphic sites ...
The primary structures of human and rabbit beta-globin mRNAs are compared. Using as a standard the extent of nucleotide substitutions inferred from the hyp... F C,Kafatos,Efstratiadis,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 123发表...
Gamma delta beta-thalassemia due to a de novo mutation deleting the 5' beta-globin gene activation-region hypersensitive sites. gamma delta beta-Thalassemia is a rare disorder of hemoglobin biosynthesis, characterized molecularly by partial or complete deletions of the beta-globin g... M C,Driscoll...
Human γ-globin genes silenced independently of other genes in the ,-globin locus. Nature, 1991, 350∶252-254.Dillon N, Grosveld F. 1991. Human gamma-globin genes silenced in- dependently of other genes in the beta-globin locus. Nature 350:252- 254. http://dx.doi.org/10.1038/350252a...
The human beta-globin locus is a highly complex genetic system that has become a classical model for studying the regulation of eukaryotic gene expression. The locus consists of five functional beta-like globin genes, epsilon- Ggamma-Agamma-delta-beta and a powerful upstream regulatory element, ...
The transgenic mouse system offers a new means for creating animals that make a specified mutant gene product, and we have used this system to create a series of mice that contain the human beta s-globin gene. These animals express this gene in the appropriate tissues and at the same point...
Here we show the human beta-globin locus is divided into three differentially activated chromatin subdomains. Large transcripts precisely delineate the active domains at key cell cycle points associated with chromatin transitions and remodeling. We identify an element that initiates these transcripts, ...
The experiments suggested that the observed imbalance in alpha/beta production was due to either differential rates of initiation of chain or quantitative differences in the amounts of the specific mRNAs present in the . 展开 被引量: 10
Expression of human locus control region (LCR) and beta-globin promoter has been recognized as an important factor in time- and tissue-specific expression event. DNA methylation can affect the transcriptional activity of specific genes. To investigate the methylation mechanism in the regulation of LCR...