Therapeutic haemoglobin syn- thesis in [β]-thalassaemic mice expressing lentivirus-encoded human [β]-globin. Nature 2000;406:82-6.May C,Rivella S,Callegari J,et al.Therapeutic haemoglobin synthesis in β-thal
SANDERS-HAIGH L, ANDERSON F, FRANCKE U: The ,B-globin gene is on the short arm of human chromosome 11. Nature 283:683-686, 1980Jeffreys AJ, Craig IW, Francke U. Localisation of the G gamma-, A gamma-, delta- and beta-globin genes on the short arm of human chromosome 11. Nature...
Human beta-globin locus control region: analysis of the 5′ DNase I hypersensitive site HS 2 in transgenic mice. Proc Natl Acad Sci USA, 88 (1991), p. 1626 CrossrefView in ScopusGoogle Scholar 6 D Talbot, S Philipsen, P Fraser, F Grosveld Detailed analysis of the site 3 region of ...
Correct human beta-globin mRNA has been restored in erythroid cells from transgenic mice carrying the human gene with beta-globin IVS2-654 splice mutation ... T Suwanmanee,H Sierakowska,G Lacerra,... - 《Molecular Pharmacology》 被引量: 139发表: 2002年 Detection of two tissue-specific DNA...
The human beta-globin locus is a highly complex genetic system that has become a classical model for studying the regulation of eukaryotic gene expression. The locus consists of five functional beta-like globin genes, epsilon- Ggamma-Agamma-delta-beta and a powerful upstream regulatory element, ...
The beta-globin gene is on the short arm of human chromosome 11. Investigations on the regulation of human globin gene expression are assisted by a knowledge of the chromosomal location of the globin genes. Previous studies 1 have mapped the α-globin locus to human chromosome (HC) 16 and ...
The hemoglobin disorders are highly prevalent, recessive genetic diseases in which coinheritance of 2 defective globin alleles results in severe hematologic disease. In patients with sickle cell anemia, the beta chain of hemoglobin S contains a substitution of valine for glutamic acid at position 6....
5. Developmental regulation of the human beta-globin locus and the role of the O and P regions in beta-like globin gene expression. [D] . Bomhoff, Anna Louise. 2007 机译:人类β-球蛋白基因座的发育调控以及O和P区在β样球蛋白基因表达中的作用。 6. DNase I Hypersensitivity and ϵ-Glob...
Mutations in the CNGB3 gene encoding the beta-subunit of the cone photoreceptor cGMP-gated channel are responsible for achromatopsia (ACHM3) linked to chromosome 8q21. Hum. Mol. Genet. 9, 2107–2116 (2000). Article CAS PubMed Google Scholar Avela, K. et al. Gene encoding a new RING-...
We report here a new human α-globin gene rearrangement carrying the two normal, α2 and α1, and two hybrid, α1/α2, globin genes in