Background Clustered Regularly Interspaced Short Palindromic Repeats-associated technology may allow for efficient and highly targeted gene editing in single-cell embryos. This possibility brings human germline editing into the focus of ethical and legal debates again. Main body Against this background, ...
With the advent of efficient, easy-to-use genome editing by CRISPR–Cas9, editing human embryos is now possible, providing tremendous opportunities to study gene function and cell fate in early human development. The technique can also be used to modify the human germline. Unresolved questions abo...
byPublic Library of Science Credit: CC0 Public Domain The first reported instance of germline gene editing in humans was bad science as well as bad ethics, according to a commentary publishing April 30 in the open-access journalPLOS Biologyby Haoyi Wang of the Institute of Zoology, Chinese Aca...
Internationally,UNESCO has called for a banon human germline gene editing. And the "Convention for the Protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine" – theOviedo Convention– specifies that "an intervention seeking to modify the ...
germline genes - those contained in sperm and eggs - to prevent offspring from developing devastating genetic diseases. At the same time, the potential for gene editing to alter human inheritance also alarms many scientists, prompting some to argue that germline editing should be prohibited ...
This paper critiques the restrictive criteria for germline genome editing recently proposed by Chin, Nguma, and Ahmad in this journal. While praising the authors for resisting fervent calls for an outright ban on clinical applications of the technology, this paper argues that their approach is never...
In the U.S., scientists can perform laboratory embryo research only with private, not federal taxpayer, funding, as the Oregon team did. Any attempt to study germline editing in pregnant women would require permission from the Food and Drug Administration, which is currently prohibited by Congres...
possible explanation is that the disease gene set may contain a disproportionately lower number of genes expressed in the germline[363]. This is because variants in such genes might be expected to be more effectively repaired by transcription-coupled repair (transcription-coupled repair in the ...
Oct 29, 2024|NEWS Scientists at deCODE genetics/Amgen, and their collaborators have discovered six novel genes with rare germline variants that associate with cancer risk. The findings are published today in Nature Genetics under the title “Gene-based burden tests of rare germline variants identify...
With the advent of efficient, easy-to-use genome editing by CRISPR–Cas9, editing human embryos is now possible, providing tremendous opportunities to study gene function and cell fate in early human development. The technique can also be used to modify the human germline. Unresolved questions ...