HUMAN GERMLINE GENE EDITING: ENGINEERING AN UNSTOPPABLE TRAINCHEN, WESLEY W.Southern California Interdisciplinary Law Journal
With the advent of efficient, easy-to-use genome editing by CRISPR–Cas9, editing human embryos is now possible, providing tremendous opportunities to study gene function and cell fate in early human development. The technique can also be used to modify the human germline. Unresolved questions ...
But the technology can also be used to repair a defective gene in a sperm or egg cell, or in an embryo that’s only a few days old. In these cases, called germline editing, the new gene would be passed to future generations. This could change the genetic makeup of humans, in possib...
Technological developments in gene editing raise high expectations for clinical applications, first of all for somatic gene editing but in theory also for germline gene editing (GLGE). GLGE is currently not allowed in many countries. This makes clinical applications in these countries impossible now...
Should human genome editing be limited to somatic cells, or should germline genome editing also be permitted? Should (apparently) permissible human genome editing be limited to therapeutic purposes, or should enhancement purposes also be permitted? Who d
editingGermlineHumanembryoThe ethical issues associated with germline gene modification and embryo research are some of the most contentious in current international science policy debates. In this paper, we argue that new genetic techniques, such as CRISPR, demonstrate that there is an urgent need ...
The first reported instance of germline gene editing in humans was bad science as well as bad ethics, according to a commentary publishing April 30 in the open-access journal PLOS Biology by Haoyi Wang of the Institute of Zoology, Chinese Academy of Scie
Internationally,UNESCO has called for a banon human germline gene editing. And the "Convention for the Protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine" – theOviedo Convention– specifies that "an intervention seeking to modify the ...
Last weekin First Opinion, six experts explored the use of gene editing to fix a defective gene in a sperm or egg cell, or in an embryo that’s only a few days old. This technique, called germline editing, raises ethical questions because the edited gene would be passed to future genera...
germline genes - those contained in sperm and eggs - to prevent offspring from developing devastating genetic diseases. At the same time, the potential for gene editing to alter human inheritance also alarms many scientists, prompting some to argue that germline editing should be prohibited ...