But the technology can also be used to repair a defective gene in a sperm or egg cell, or in an embryo that’s only a few days old. In these cases, called germline editing, the new gene would be passed to future generations. This could change the genetic makeup of humans, in possib...
C。解析:文章中提到“In addition to the risks, gene editing also raises ethical questions. For example, is it right to edit the human germline, which would affect future generations? Some people argue that gene editing could be used to create "designer babies" with specific traits, which is ...
Germ-line gene editing, on the other hand, would have hereditary effects. This raises special concerns about medical mishaps. Medical risks are, however, not the only kinds of risks in the case of germline gene editing. Discussed here are not the medical risks, but the social and moral ...
What do we do now?: Responding to claims of germline gene editing in humansMegan Allyse PhDYvonne Bombard PhDRosario Isasi JD, MPHMarsha Michie PhDKiran Musunuru MD, PhDKelly E. Ormond MS, LCGCGenetics in Medicine
Many oppose germline modification under any circumstances, reasoning that an eventual consequence could be non-therapeutic genetic enhancement.13 It is clear that the ethical boundaries, within which CRISPR/Cas9 can be used, remain to be fully determined. 展开 关键词:...
CRISPR. What is it? And why is the scientific community so fascinated by the potential applications of this gene-editing technology? Starting with its definition, we explain how this technology harnesses an ancient bacteria-based defense system — and how it will impact the world around us today...
TheInternational Commission on the Clinical Use of Human Germline Genome Editingconvened on Aug. 13 to hash out guidelines about editing humanembryos. The goal is to provide a framework that researchers around the globe can consult to ensure their work is in line with scientific consensus. ...
Within the last decades, genome-editing techniques such as CRISPR/Cas, TALENs, Zinc-Finger Nucleases, Meganucleases, Oligonucleotide-Directed Mutagenesis and base editing have been developed enabling a precise modification of DNA sequences. Such techniqu
et al. A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li-Fraumeni-like families. Nat. Commun. 6, 8383 (2015). CAS PubMed Google Scholar Aoude, L. G. et al. Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma. ...
If a cell loses control of gene expression, what happens? How is an embryo different than a somatic cell? How do T-cells help in somatic mutation? How do somatic cells get created from the gametes? How are somatic and germline mutations different? What process occurs when chromosomes are in...