Define germline. germline synonyms, germline pronunciation, germline translation, English dictionary definition of germline. or germ line n. 1. The gamete-producing cells in a sexually reproducing organism, by means of which genetic material is passed on
gene editingbioethicsassisted reproductive technologymedicinepoliticsregulationAdvances in gene editing have recently received significant scientific and media attention. Gene editing, especially CRISPR-Cas9, has revived multiple longstandSocial Science Electronic Publishing...
The regulations require that the riskiest of techniques — including human gene editing — be approved by China’s health ministry first. Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 24,99 € / 30 days cancel any...
DefinitionGenome Editing der Keimbahn umfasst an der Keimzelle oder dem Embryo vor-genommene genetische Veränderungen, die prinzipiell Auswirkungen auf alle Zel-len des Embryos haben und von der aus dem Embryo hervorgehenden Person an nachfolgende Generationen weitervererbt werden können....
ChinaGeneeditingGermlineHumanembryoThe ethical issues associated with germline gene modification and embryo research are some of the most contentious in current international science policy debates. In this paper, we argue that new genetic techniques, such as CRISPR, demonstrate that there is an urgent...
The first reported instance of germline gene editing in humans was bad science as well as bad ethics, according to a commentary publishing April 30 in the open-access journal PLOS Biology by Haoyi Wang of the Institute of Zoology, Chinese Academy of Scie
(2017). Designing Ethical Trials of Germline Gene Editing. New England Journal of Medicine, 377(20), 1911-1913. 这文章让我想起当年农大面试理科实验班时的问题。如果我没记错,问这个问题的应该是当时生院院长,他让我们回答现在面临的阻碍生物研究的最大问题是什么。作为一个纯粹被高中生物吸引,基本不了解...
Some of the concerns raised about somatic gene transfer are related to the possibility that it could inadvertently lead to germline gene transfer.;Germline gene transfer at the te and zygote stages have significant risks.;Beyond the medical risks to the potential child, a number of long-standing...
An integrated network of androgen receptor, polycomb, and TMPRSS2–ERG gene fusions in prostate cancer progression. Cancer Cell 17, 443–454 (2010). CAS PubMed PubMed Central Google Scholar Wang, D. et al. Reprogramming transcription by distinct classes of enhancers functionally defined by ...
Cas9-mediated gene editing is a powerful tool for addressing research questions in arthropods. Current approaches rely upon delivering Cas9 ribonucleoprotein (RNP) complex by embryonic microinjection, which is challenging, is limited to a small number of species, and is inefficient even in optimized ...