To investigate the mechanism of Golgi matrix protein 130(GM130) regulating the antiviral immune response of TLR3 after herpes simplex virus type 1(HSV-1) infection of microglia cells. We explored the regulatory effects of berberine on the immune response
The experiments descri- bed above implied that MARCO can interact directly with HSV-1 gC. We next used purified MARCO to verify that gC can bind to 3 MARCO 2 3 OLR1 2 MARCO Syndecan-1 1 1 0 0 5 10 15 20 Total gB added (nM) 0 0 20 40 60 Total gC added (nM) OLR1 SCARA3 ...
This invention concerns the less-studied human T-cell response to HSV-1. HSV infections are thought to be permanent, due to infection of sensory ganglion neurons. Infection is most accurately diagnosed by IgG serology: patients remain seropositive for life. The prevalence of HSV-1 infection is ...
Fast-replicating neurotropic herpesviruses exemplified by herpes simplex virus-1 (HSV-1) naturally infect the central nervous system (CNS). However, most individuals intrinsically suppress the virus during a primary infection and preclude it from signifi
Recurrent HSV-1 infection has various clinical features. This case report addresses three differences in the oral clinical manifestation of HSV-1 with the same high level of IgG titers reaching 200 U/mL. IgG antibody level indicates the state of recurrency but does not correlate with clinical ...
IP-10 was moderately but significantly elevated (2-fold) above the level found in unsensitized hosts, whereas Mig was 15-fold higher in the immunized mice. In normal ears, not virus challenged, constitutive levels of IP-10 were seen in 2 out of 10 ear pinnae tested, while no Mig (<3...
HSV-2 Candidate Vaccine Virus Deleted in Glycoprotein D (螖gD-2) Elicits High-Titer IgG2 Antibodies with Antibody Dependent Cell Mediated Cytotoxicity (ADCC) Activity, Protects Mice from Skin and Vaginal Challenge with Cinical Isolates of HSV-1 and HSV-2, and Prevents the Establishment of ...
FIG. 4 is a graph illustrating the reactivity of human serum pools with recombinant HSV-2 tegument proteins, each plated at a 1:5 dilution for use as capture antigen. Binding of human IgG from pooled sera of donors with HSV-2, or without either HSV-1 or HSV-2 infection was detected ...
with HSV-1 (Figure 2b). When we extended the HSV-1 infection time to 48 h, a similar trend was observed. Both the gD positivity and the viral titres were remarkably higher in the U937 cells refractory to NF-κB activation as compared with those in which NF-κB activation was normal (...
This process occurs under normal homeostatic conditions as well as patholo- gical conditions, and it is the cellular response to these extracellular stimuli that determines the fine balance between cell survival and death. The Project of Ex-vivo Vein Graft Engineering via Transfection (PREVENT) ...