Recurrent HSV-1 infection has various clinical features. This case report addresses three differences in the oral clinical manifestation of HSV-1 with the same high level of IgG titers reaching 200 U/mL. IgG antibody level indicates the state of recurrency but does not correlate with clinical ...
HSV-2 Candidate Vaccine Virus Deleted in Glycoprotein D (螖gD-2) Elicits High-Titer IgG2 Antibodies with Antibody Dependent Cell Mediated Cytotoxicity (ADCC) Activity, Protects Mice from Skin and Vaginal Challenge with Cinical Isolates of HSV-1 and HSV-2, and Prevents the Establishment of ...
From left to right: gene expression levels of the markers rendered at each cell, smoothed expression, and 3D rendering of clusters as smooth surfaces. Top: immune compartment represented by the germinal center (CXCL13), IgG plasma cells (IGHG1), and macrophages (LYZ); bottom: tumor and ...
Indeed, only a trend toward an association between the presence of IgG anti-hepatitis A virus, anti-herpes simplex virus (HSV) type 2, and anti-Brucella were observed (see Additional file 1: Table S3). In addition, none of these common pathogens showed a significant correlation with NKG2C ...
As a result of the dependence on HMGB protein for the optimal production of inflammatory responses induced by RNA and DNA, pan-HMGB silenced MEFs had weaker resistance against vesicular stomatitis virus (VSV) and HSV-1 infection. Yanai et al. [113] further investigated the relationship between ...
is a genetically modified oncolytic herpes simplex virus type 1 (HSV-1) used to treat advanced melanoma1,2. Currently, most OVs are based on human pathogenic viruses, such as HSV and adenoviruses; thus, attenuation of virulence by removal of toxic viral genes is generally required. However, ...
gD is derived from the HSV (herpes simplex virus) envelope glycoprotein D. MCF-7, SK-BR-3 and MCF10DCIS.com cells were transfected using FuGENE 6 Transfection Reagent (Promega), with the DNA constructs or siRNA oligos mixed in Opti-MEM (Life Technologies). Cells grown in 2D were incubated...
In an effort to screen for alternative gene transfer systems for CLL cells, replication-defective herpes simplex virus type 1 (HSV-1) was shown to result in a high transduction efficiency for malignant B cells 10, 11. Nevertheless, clinical applications of HSV-1–based vectors appear problematic...
HPV-16 PsVs were used to deliver a herpes simplex thymidine kinase (HSV-tk) gene to ovarian tumour cells in mice and were shown to have antitumour effects [188]. Delivery of the model ovalbumin (OVA) antigen in HPV-16 PsVs was also shown to generate OVA-specific CD8+ T cells immune...
Herpes Simplex Virus (HSV), which causes painful blisters and sores on various parts of the body, and Herpes Zoster, which causes chicken pox (initial infection) and shingles (upon recurrence), are members of the same family of viruses which require the expression of both ICP4 and ICP47 to...