To investigate the mechanism of Golgi matrix protein 130(GM130) regulating the antiviral immune response of TLR3 after herpes simplex virus type 1(HSV-1) infection of microglia cells. We explored the regulatory effects of berberine on the immune response
Afterward, the sections were incubated with a secondary biotinylated IgG antibody followed by an anti-biotin-peroxidase reagent for a duration of 20 min. The detection of signals was accomplished using a DAB reagent (Mxb Biotechnologies), and the nuclei were counterstained with hematoxylin. Slide...
HSV-1 is a significant human pathogen that can result in progressive corneal damage leading to visual impairment1. In experimental models of HSV-1 keratitis, the host inflammatory response to the pathogen is the principal driver of tissue pathology which includes neovascularization (NV)2, lymphangioge...
HSV-1gKWe previously reported that vaccination of BALB/c mice with the baculovirus expressed HSV-1 glycoprotein K (gK) or passive transfer of gK purified IgG to naive BALB/c mice causes severe exacerbation of HSV-1 induced corneal scarring following ocular challenge. In addition, a productive ...
However, HSV2 must have been restricted to the mouth mostly, where HSV1 already resided in many hominins, making them resilient to HSV2. Now You Know Who To Really Blame For Herpes Result of cross-reactivity tests Pathogen CMV/FAM Internal control Cy5 Parvovirus B19 - + TTV - + HPV - ...
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Fast-replicating neurotropic herpesviruses exemplified by herpes simplex virus-1 (HSV-1) naturally infect the central nervous system (CNS). However, most individuals intrinsically suppress the virus during a primary infection and preclude it from signifi
Since the antibody against HSV-2 infection (IgG) provides life-long immunity [35], we fitted I+R to the observed data of the number of sero-positive cases for the estimation of c and ϕ. To estimate c and ϕ, endemic equilibria of I i and R i were solved numerically with varied...
Though lymphotoxin (LT) is highly expressed by type I helper T (Th1) cells, its contribution to CD4+ T cell differentiation during infections and diseases remains a mystery. In HSV-1 infection, we observed that LTβR signaling is required to limit the Th
The antisense oligonucleotide targeted E2F transcription factor result- ing in a block of cell cycle gene expression.2,4,29 Unfortunately, these strategies have failed when applied to peripheral arterial disease. The drug eluting stent for the treatment of intimal hyperplasia in the coronary arteries ...