Pathway pathology: how to identify signaling pathways in mouse models of human breast cancerdoi:10.1016/S0959-8049(02)80936-4SDOSEuropean Journal of Cancer
Accordingly, the ability to rationally manipulate these interactions will represent a key enabling technology for understanding the properties of natural cellular networks, for building new biological responses into cells, and even as a starting point for therapeutic intervention in certain human diseases....
as cholesterol is an integral part of lipid rafts on the plasma membrane and lipid-rich regions in intracellular membranes. As such, cholesterol has been shown to regulate signaling hubs in cellular membranes for several critical pathways [58,59]. ...
J. Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development. J. Immunol. 170, 5834–5841 (2003). Article CAS PubMed Google Scholar Hosoya, T. et al. GATA-3 is required for early T lineage progenitor development. J....
is measured using a grip system to determine weakness. Slowness is described as a positive response to either one of the following two questions: “Do you have difficulty [expected to last more than 3 months] walking 100 m because of a health problem?” and “Do you have difficulty [...
To determine how intracellular Ca[sup 2+] and membrane voltage regulate the gating of large conductance Ca[sup 2+]-activated K[sup +] (BK) channels, we exa... Horrigan,Frank,T.,... - 《Journal of General Physiology》 被引量: 383发表: 2002年 The role of Ca(2+) signaling in the...
cross-section. the progenitor glial cells proliferate and give rise to neuroblasts. each of the neurons executes the same molecular program to determine its migration behavior over time. for example, a neuroblast at the svz activates gaba a receptors in response to gaba concentrations in its ...
Research shows, though, that pain signaling, as well as the sensations the body perceives as pain, can be more complex than this scenario. Read on to learn more about why we feel pain and gain a greater understanding of the gate control theory of pain. ...
model validation and testable hypothesis regarding specific conformational changes that control bond profiles, thereby suggesting structural mechanisms for the inner workings of the TCR mechanosensing machinery and plausible explanations of why and how force may amplify TCR signaling and antigen discrimination....
Additionally, mRNA-based therapies can specifically change which genes are expressed to treat diseases like cancer. In the future, we may discover similar therapies for alcohol and substance use disorder. These treatments could potentially target important signaling pathways linked to addiction, altering ...